Human RASD2 Recombinant Protein (RPPB4412)

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SKU:
RPPB4412
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96D21

Description

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Product Name:Human RASD2 Recombinant Protein
Product Code:RPPB4412
Size:20µg
Species:Human
Target:RASD2
Synonyms:GTP-binding protein Rhes, Ras homolog enriched in striatum, TEM2, RASD2, Rhes, Tumor endothelial marker 2, RASD Family Member 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:RASD2 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMMKTLSS GNCTLSVPAK NSYRMVVLGA SRVGKSSIVS RFLNGRFEDQ YTPTIEDFHR KVYNIRGDMY QLDILDTSGN HPFPAMRRLS ILTGDVFILV FSLDNRESFD EVKRLQKQIL EVKSCLKNKT KEAAELPMVI CGNKNDHGEL CRQVPTTEAE LLVSGDENCA YFEVSAKKNT NVDEMFYVLF SMAKLPHEMS PALHRKISVQ YGDAFHPRPF CMRRVKEMDA YGMVSPFARR PSVNSDLKYI KAKVLREGQA RERDKCTIQ

RASDFamily Member 2 (RASD2) which binds to GTP and owns a GTPase activity is a partof the Ras super family of small GTPases. RASD2 regulates signaling pathwaysinvolving G-proteins-coupled receptor and heterotrimeric proteins. RASD2encodes a Ras-related protein that enriched in striatum.

RASD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 289 amino acids (1-266 a.a) and having a molecular mass of 32.8 kDa.RASD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RASD2: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Belongs to the small GTPase superfamily. RasD family.
UniProt Protein Details:

Protein type:G protein, monomeric, RasD; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: plasma membrane

Molecular Function:GTPase activity; GTP binding; ubiquitin conjugating enzyme binding; G-protein beta-subunit binding

Biological Process: positive regulation of protein sumoylation; synaptic transmission, dopaminergic; positive regulation of protein kinase B signaling cascade; metabolic process; small GTPase mediated signal transduction; locomotory behavior; negative regulation of protein ubiquitination

NCBI Summary:This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. [provided by RefSeq, Jul 2008]
UniProt Code:Q96D21
NCBI GenInfo Identifier:21362868
NCBI Gene ID:23551
NCBI Accession:Q96D21.1
UniProt Secondary Accession:Q96D21,O95520, Q5THY8,
UniProt Related Accession:Q96D21
Molecular Weight:30,366 Da
NCBI Full Name:GTP-binding protein Rhes
NCBI Synonym Full Names:RASD family, member 2
NCBI Official Symbol:RASD2��
NCBI Official Synonym Symbols:Rhes; TEM2; MGC:4834��
NCBI Protein Information:GTP-binding protein Rhes; tumor endothelial marker 2; Ras homolog enriched in striatum
UniProt Protein Name:GTP-binding protein Rhes
UniProt Synonym Protein Names:Ras homolog enriched in striatum; Tumor endothelial marker 2
Protein Family:GTP-binding protein
UniProt Gene Name:RASD2��
UniProt Entry Name:RHES_HUMAN
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