Human RAP2A Recombinant Protein (RPPB4404)
- SKU:
- RPPB4404
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10114
Description
| Product Name: | Human RAP2A Recombinant Protein |
| Product Code: | RPPB4404 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAP2A |
| Synonyms: | Ras-related protein Rap-2a, RbBP-30, RAP2A, KREV, RAP2, K-REV. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAP2A solution (1 mg/ml) 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYEKVP VILVGNKVDL ESEREVSSSE GRALAEEWGC PFMETSAKSK TMVDELFAEI VRQMNYAAQP DKDDPCCSAC |
RAP2A belongs to the RAS oncogene family and a Ras-like small G protein. The RAP2A protein shares 60% identity with Rap1A and exhibits a carboxy-terminal CAAX motif and 2 upstream cysteines similar to those of the H-Ras, K-Ras and N-Ras proteins. In contrast with Rap1A and Rap1B, overexpression of RAP2A doesn�t obstruct the Ras signaling pathway.
RAP2A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 200 amino acids (1-180 a.a.) and having a molecular mass of 22.4kDa. The RAP2A is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. |
| UniProt Code: | P10114 |
| NCBI GenInfo Identifier: | 131852 |
| NCBI Gene ID: | 5911 |
| NCBI Accession: | P10114.1 |
| UniProt Secondary Accession: | P10114,Q5JSC1, Q5JSC2, B2RCJ1, |
| UniProt Related Accession: | P10114 |
| Molecular Weight: | 20,615 Da |
| NCBI Full Name: | Ras-related protein Rap-2a |
| NCBI Synonym Full Names: | RAP2A, member of RAS oncogene family |
| NCBI Official Symbol: | RAP2A�� |
| NCBI Official Synonym Symbols: | KREV; RAP2; K-REV; RbBP-30�� |
| NCBI Protein Information: | ras-related protein Rap-2a |
| UniProt Protein Name: | Ras-related protein Rap-2a |
| UniProt Synonym Protein Names: | RbBP-30 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAP2A�� |
| UniProt Entry Name: | RAP2A_HUMAN |
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