Human RANGRF Recombinant Protein (RPPB4400)

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SKU:
RPPB4400

Description

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Product Name:Human RANGRF Recombinant Protein
Product Code:RPPB4400
Size:20µg
Species:Human
Target:RANGRF
Synonyms:Ran guanine nucleotide release factor, RanGNRF, Ran-binding protein MOG1, RANGRF, MOG1, HSPC165, HSPC236, MDS5.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:RANGRF protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMEPTRD CPLFGGAFSA ILPMGAIDVS DLRPVPDNQE VFCHPVTDQS LIVELLELQA HVRGEAAARY HFEDVGGVQG ARAVHVESVQ PLSLENLALR GRCQEAWVLS GKQQIAKENQ QVAKDVTLHQ ALLRLPQYQT DLLLTFNQPP PDNRSSLGPE NLSPAPWSLG DFEQLVTSLT LHDPNIFGPQ

RANGRF is a protein which acts as a guanine nucleotide release factor in mouse and regulates the expression and function of the Nav1.5 cardiac sodium channel in human. RANGRF also controls the intracellular trafficking of RAN. In cardiac cells, the RANGRF appears to regulate the cell surface localization of SCN5A.

RANGRF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-186 a.a) and having a molecular mass of 23kDa.RANGRF is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9HD47
NCBI GenInfo Identifier:295317377
NCBI Gene ID:29098
NCBI Accession:NP_001171272.1
UniProt Secondary Accession:Q9HD47,Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2 D3DTR6
UniProt Related Accession:Q9HD47
Molecular Weight:12,900 Da
NCBI Full Name:ran guanine nucleotide release factor isoform B
NCBI Synonym Full Names:RAN guanine nucleotide release factor
NCBI Official Symbol:RANGRF��
NCBI Official Synonym Symbols:MOG1; HSPC165; HSPC236; RANGNRF��
NCBI Protein Information:ran guanine nucleotide release factor; MOG1 homolog; ran-binding protein MOG1
UniProt Protein Name:Ran guanine nucleotide release factor
UniProt Synonym Protein Names:Ran-binding protein MOG1
Protein Family:Nuclear import protein
UniProt Gene Name:RANGRF��
UniProt Entry Name:MOG1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9HD47
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