Human RAMP3 Recombinant Protein (RPPB4396)
- SKU:
- RPPB4396
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60896
Description
| Product Name: | Human RAMP3 Recombinant Protein |
| Product Code: | RPPB4396 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAMP3 |
| Synonyms: | Receptor (calcitonin) activity modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, RAMP3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RAMP3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MRAGGCNETG MLERLPLCGK AFADMMGKVD VWKWCNLSEF IVYYESFTNC TEMEANVVGC YWPNPLAQGF ITGIHRQFFS NCTVDRVHLE DPPDEV |
Receptor activity modifying protein 3 (RAMP3) belongs to the RAMP family of single-transmembrane-domain proteins, named receptor (calcitonin) activity modifying proteins (RAMPs). RAMP3 is needed to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR acts as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. The existence of RAMP3 effects CRLR to function as an adrenomedullin receptor.
RAMP3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 116 amino acids (24-118 a.a) and having a molecular mass of 13kDa. RAMP3 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAMP3: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 7p13-p12 Cellular Component: cell surface; integral to plasma membrane; lysosome; plasma membrane; intracellular; receptor complex Molecular Function:protein binding; coreceptor activity; receptor activity; protein transporter activity Biological Process: intracellular protein transport; protein transport; receptor internalization; calcium ion transport; negative regulation of transcription, DNA-dependent; positive regulation of receptor recycling; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60896 |
| NCBI GenInfo Identifier: | 11134424 |
| NCBI Gene ID: | 10268 |
| NCBI Accession: | O60896.1 |
| UniProt Secondary Accession: | O60896,Q7Z2Y1, |
| UniProt Related Accession: | O60896 |
| Molecular Weight: | 148 |
| NCBI Full Name: | Receptor activity-modifying protein 3 |
| NCBI Synonym Full Names: | receptor (G protein-coupled) activity modifying protein 3 |
| NCBI Official Symbol: | RAMP3�� |
| NCBI Protein Information: | receptor activity-modifying protein 3; CRLR activity-modifying protein 3; receptor activity modifying protein 3; receptor-activity-modifying protein 3; receptor (calcitonin) activity modifying protein 3; calcitonin receptor-like receptor activity modifyin |
| UniProt Protein Name: | Receptor activity-modifying protein 3 |
| UniProt Synonym Protein Names: | Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3 |
| Protein Family: | Receptor activity-modifying protein |
| UniProt Gene Name: | RAMP3�� |
| UniProt Entry Name: | RAMP3_HUMAN |
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