Human RAB8 Recombinant Protein (RPPB4342)
- SKU:
- RPPB4342
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92930
Description
| Product Name: | Human RAB8 Recombinant Protein |
| Product Code: | RPPB4342 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAB8 |
| Synonyms: | Ras-related protein Rab-8B, RAB8B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The RAB8 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAKTYDY LFKLLLIGDS GVGKTCLLFR FSEDAFNTTF ISTIGIDFKI RTIELDGKKI KLQIWDTAGQ ERFRTITTAY YRGAMGIMLV YDITNEKSFD NIKNWIRNIE EHASSDVERM ILGNKCDMND KRQVSKERGE KLAIDYGIKF LETSAKSSAN VEEAFFTLAR DIMTKLNRKM NDSNSAGAGG PVKITENRSK KTSFFRC |
�RAB8, Member RAS Oncogene Family (RAB8B), is a low molecular mass monomeric GTPases which localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB8 takes part in polarized vesicular trafficking and neurotransmitter release and also in cell junction dynamics in Sertoli cells. RAB proteins function in intracellular vesicle transport by aiding in the docking or fusion of vesicles with their target membranes.
RAB8 Human Recombinant produced in E. coli is a single polypeptide chain containing 227 amino acids (1-204) and having a molecular mass of 25.7kDa. RAB8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB8B: May be involved in vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 15q22.2 Cellular Component: peroxisomal membrane; phagocytic vesicle Molecular Function:GDP binding; protein binding; receptor binding Biological Process: antigen processing and presentation; cilium biogenesis; protein import into peroxisome membrane; protein secretion; vesicle docking during exocytosis |
| NCBI Summary: | RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q92930 |
| NCBI GenInfo Identifier: | 13638434 |
| NCBI Gene ID: | 51762 |
| NCBI Accession: | Q92930.2 |
| UniProt Secondary Accession: | Q92930,Q5JPC4, Q9P293, |
| UniProt Related Accession: | Q92930 |
| Molecular Weight: | 23,584 Da |
| NCBI Full Name: | Ras-related protein Rab-8B |
| NCBI Synonym Full Names: | RAB8B, member RAS oncogene family |
| NCBI Official Symbol: | RAB8B�� |
| NCBI Protein Information: | ras-related protein Rab-8B |
| UniProt Protein Name: | Ras-related protein Rab-8B |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB8B�� |
| UniProt Entry Name: | RAB8B_HUMAN |
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