Human RAB6A Recombinant Protein (RPPB4371)
- SKU:
- RPPB4371
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20340
Description
| Product Name: | Human RAB6A Recombinant Protein |
| Product Code: | RPPB4371 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAB6A |
| Synonyms: | Ras-related protein Rab-6A, Rab-6, RAB6A, RAB6, RAB6B, RAB6A'. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAB6A solution (1 mg/ml) contains 20mM Tris buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSTGGD FGNPLRKFKL VFLGEQSVGK TSLITRFMYD SFDNTYQATI GIDFLSKTMY LEDRTIRLQL WDTAGQERFR SLIPSYIRDS AAAVVVYDIT NVNSFQQTTK WIDDVRTERG SDVIIMLVGN KTDLADKRQV SIEEGERKAK ELNVMFIETS AKAGYNVKQL FRRVAAALPG MESTQDRSRE DMIDIKLEKP QEQPVSEGGC SC |
RAB6A is a member of the small GTPase superfamily. RAB6A may be involved in protein transport. RAB6A is a regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) and has a low GTPase activity.
RAB6A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-208) and having a molecular mass of 26.1kDa.RAB6A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB6A: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO/C1orf88. Ubiquitous. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Rab; G protein, monomeric; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: cytoplasmic vesicle; cytosol; Golgi apparatus; Golgi membrane; membrane; trans-Golgi network Molecular Function:GTP binding; GTPase activity; myosin V binding; protein binding; protein domain specific binding Biological Process: antigen processing and presentation; peptidyl-cysteine methylation; protein localization in Golgi apparatus; protein targeting to Golgi; retrograde vesicle-mediated transport, Golgi to ER; small GTPase mediated signal transduction; viral reproduction |
| NCBI Summary: | This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P20340 |
| NCBI GenInfo Identifier: | 131796 |
| NCBI Gene ID: | 5870 |
| NCBI Accession: | P20340.3 |
| UniProt Secondary Accession: | P20340,Q1W5D8, Q5U0A8, Q9UBE4, A8K133, B7Z772, F5H668 |
| UniProt Related Accession: | P20340 |
| Molecular Weight: | 19,935 Da |
| NCBI Full Name: | Ras-related protein Rab-6A |
| NCBI Synonym Full Names: | RAB6A, member RAS oncogene family |
| NCBI Official Symbol: | RAB6A�� |
| NCBI Official Synonym Symbols: | RAB6�� |
| NCBI Protein Information: | ras-related protein Rab-6A |
| UniProt Protein Name: | Ras-related protein Rab-6A |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB6A�� |
| UniProt Entry Name: | RAB6A_HUMAN |
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