Human RAB5A Recombinant Protein (RPPB4368)

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SKU:
RPPB4368
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P20339

Description

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Product Name:Human RAB5A Recombinant Protein
Product Code:RPPB4368
Size:20µg
Species:Human
Target:RAB5A
Synonyms:Ras-related protein Rab-5A, RAB5A, RAB5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The protein solution contains 20mM Tris-HCl pH-8.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQTVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQRQASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKKLPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN

RAB5A is a member of RAS oncogene family. The small GTPase, RAB5A is a crucial regulatory component of the endocytic pathway. Activation of RAB5A is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex). RAB5A is required for the fusion of plasma membranes and early endosomes.

RAB5A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 215 amino acids and having a molecular mass of 23kDa.

UniProt Protein Function:RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:

Protein type:G protein, monomeric, Rab; Motility/polarity/chemotaxis; G protein, monomeric; G protein

Chromosomal Location of Human Ortholog: 3p24-p22

Cellular Component: zymogen granule membrane; protein complex; early endosome; dendrite; terminal button; phagocytic vesicle; cytosol; actin cytoskeleton; lipid raft; ruffle; synaptic vesicle; recycling endosome; cell soma; endocytic vesicle; perinuclear region of cytoplasm; axon; cytoplasm; melanosome; plasma membrane; endosome membrane; nerve terminal; endosome

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; GDP-dissociation inhibitor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; intracellular protein transport; regulation of endosome size; early endosome to late endosome transport; positive regulation of smooth muscle cell proliferation; regulation of endocytosis; endocytosis; regulation of filopodium formation; blood coagulation; positive regulation of smooth muscle cell migration; Rab protein signal transduction; positive regulation of exocytosis

UniProt Code:P20339
NCBI GenInfo Identifier:1346958
NCBI Gene ID:5868
NCBI Accession:P20339.2
UniProt Secondary Accession:P20339,Q6FI44, B4DJA5,
UniProt Related Accession:P20339
Molecular Weight:22,178 Da
NCBI Full Name:Ras-related protein Rab-5A
NCBI Synonym Full Names:RAB5A, member RAS oncogene family
NCBI Official Symbol:RAB5A��
NCBI Official Synonym Symbols:RAB5��
NCBI Protein Information:ras-related protein Rab-5A; RAS-associated protein RAB5A
UniProt Protein Name:Ras-related protein Rab-5A
Protein Family:Ras-related protein
UniProt Gene Name:RAB5A��
UniProt Entry Name:RAB5A_HUMAN
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