Human RAB3A Recombinant Protein (RPPB4363)
- SKU:
- RPPB4363
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20336
Description
| Product Name: | Human RAB3A Recombinant Protein |
| Product Code: | RPPB4363 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAB3A |
| Synonyms: | Ras-related protein Rab-3A, RAB3A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RAB3A protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG AKQGPQLSDQ QVPPHQDCAC |
Rab3A is a member of the small GTPase superfamily, Rab family. Rab3A is a small, Ras-like GTPase expressed in neuroendocrine cells, in which Rab3A is linked with secretory vesicle membranes and regulates exocytosis. Rab3A protein may have a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
RAB3A produced in E.Coli is a single, non-glycosylated polypeptide chain containing 240 amino acids (1-220 a.a) and having a molecular mass of 27.1kDa.RAB3A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB3A: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: axon; plasma membrane; synaptic vesicle; terminal button Molecular Function:GTPase activity; myosin V binding; protein binding Biological Process: constitutive secretory pathway; glutamate secretion; neurotransmitter secretion; positive regulation of exocytosis; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle exocytosis |
| UniProt Code: | P20336 |
| NCBI GenInfo Identifier: | 131801 |
| NCBI Gene ID: | 5864 |
| NCBI Accession: | P20336.1 |
| UniProt Secondary Accession: | P20336,Q9NYE1, A8K0J4, |
| UniProt Related Accession: | P20336 |
| Molecular Weight: | 24,984 Da |
| NCBI Full Name: | Ras-related protein Rab-3A |
| NCBI Synonym Full Names: | RAB3A, member RAS oncogene family |
| NCBI Official Symbol: | RAB3A�� |
| NCBI Protein Information: | ras-related protein Rab-3A |
| UniProt Protein Name: | Ras-related protein Rab-3A |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB3A�� |
| UniProt Entry Name: | RAB3A_HUMAN |
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