Human RAB2A Recombinant Protein (RPPB4357)

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RPPB4357

Description

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Product Name:Human RAB2A Recombinant Protein
Product Code:RPPB4357
Size:20µg
Species:Human
Target:RAB2A
Synonyms:Ras-related protein Rab-2A, RAB2A, RAB2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RAB2A protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 20% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH SGSHMAYAYL FKYIIIGDTG VGKSCLLLQF TDKRFQPVHD LTIGVEFGAR MITIDGKQIK LQIWDTAGQE SFRSITRSYY RGAAGALLVY DITRRDTFNH LTTWLEDARQ HSNSNMVIML IGNKSDLESR REVKKEEGEA FAREHGLIFM ETSAKTASNV EEAFINTAKE IYEKIQEGVF DINNEANGIK IGPQHAATNA THAGNQGGQQ AGGGCC

Ras-related protein Rab-2A (RAB2A)is a member of the small GTPase superfamily. RAB protein family members are nontransforming monomeric GTP-binding proteins of the Ras superfamily, which contain four highly conserved regions involved in GTP binding and hydrolysis. In addition, RAB proteins are a fundamental part of endocytic pathways. RAB2A and RAB2B are essential for protein transport from the ER to the Golgi; RAB2A is lipid-anchored to the ER-Golgi intermediate compartment membrane whereas RAB2B is lipid anchored to the cytoplasmic side of the cell membrane. RAB2A also interacts with GOLGA2.

RAB2A produced in E.Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (1-212 a.a) and having a molecular mass of 26.1kDa.RAB2A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Rab2: Required for protein transport from the endoplasmic reticulum to the Golgi complex. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 8q12.1-q12.2

Cellular Component: cytosol; Golgi apparatus; Golgi membrane; lysosomal membrane; nucleus

Molecular Function:GDP binding; GTP binding; GTPase activity; protein binding

Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis

NCBI Summary:The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:P61019
NCBI GenInfo Identifier:46577636
NCBI Gene ID:5862
NCBI Accession:P61019.1
UniProt Secondary Accession:P61019,P08886, B2R5W8, B4DMQ5,
UniProt Related Accession:P61019
Molecular Weight:24kDa
NCBI Full Name:Ras-related protein Rab-2A
NCBI Synonym Full Names:RAB2A, member RAS oncogene family
NCBI Official Symbol:RAB2A��
NCBI Official Synonym Symbols:LHX; RAB2��
NCBI Protein Information:ras-related protein Rab-2A
UniProt Protein Name:Ras-related protein Rab-2A
Protein Family:Ras-related protein
UniProt Gene Name:RAB2A��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P61019
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