Human RAB1A Recombinant Protein (RPPB4349)

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SKU:
RPPB4349
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62820

Description

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Product Name:Human RAB1A Recombinant Protein
Product Code:RPPB4349
Size:10µg
Species:Human
Target:RAB1A
Synonyms:RAB1A member RAS oncogene family, YPT1-related protein, DKFZp564B163, GTP binding protein Rab1a, Rab GTPase YPT1 homolog.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The RAB1A protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN NVKQWLQEID RYASENVNKL LVGNKCDLTT KKVVDYTTAK EFADSLGIPF LETSAKNATN� VEQSFMTMAA EIKKRMGPGA TAGGAEKSNV KIQSTPVKQS GGGCC

RAB1A belongs to the ras-related superfamily. Rab proteins have a central part in either in endocytosis or in biosynthetic protein transport. Rab1a protein controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus.

RAB1A produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (1-205.a.a) and having a molecular mass of 24.8kDa. RAB1A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RAB1A: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rab family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; early endosome; melanosome; cytosol

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: ER to Golgi vesicle-mediated transport; cell migration; endocytosis; virus assembly; melanosome transport; vesicle-mediated transport; growth hormone secretion; intracellular protein transport; defense response to bacterium; vesicle transport along microtubule; autophagy; cilium biogenesis; mitotic cell cycle; Rab protein signal transduction; Golgi organization and biogenesis; autophagic vacuole formation

NCBI Summary:This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]
UniProt Code:P62820
NCBI GenInfo Identifier:51338603
NCBI Gene ID:5861
NCBI Accession:P62820.3
UniProt Related Accession:P62820
Molecular Weight:
NCBI Full Name:Ras-related protein Rab-1A
NCBI Synonym Full Names:RAB1A, member RAS oncogene family
NCBI Official Symbol:RAB1A��
NCBI Official Synonym Symbols:RAB1; YPT1��
NCBI Protein Information:ras-related protein Rab-1A
UniProt Protein Name:Ras-related protein Rab-1A
UniProt Synonym Protein Names:YPT1-related protein
Protein Family:Ras-related protein
UniProt Gene Name:RAB1A��
UniProt Entry Name:RAB1A_HUMAN
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