Human RAB18 Recombinant Protein (RPPB4348)

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SKU:
RPPB4348
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NP72

Description

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Product Name:Human RAB18 Recombinant Protein
Product Code:RPPB4348
Size:10µg
Species:Human
Target:RAB18
Synonyms:RAB18 member RAS oncogene family, RAB18LI1, WARBM3, RAB18 small GTPase, ras-related protein Rab-18.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RAB18 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5) and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MASMTGGQQM GRGSHMDEDV LTTLKILIIG ESGVGKSSLL LRFTDDTFDP ELAATIGVDF KVKTISVDGN KAKLAIWDTA GQERFRTLTP SYYRGAQGVI LVYDVTRRDT FVKLDNWLNE LETYCTRNDI VNMLVGNKID KENREVDRNE GLKFARKHSM LFIEASAKTC DGVQCAFEEL VEKIIQTPGL WESENQNKGV KLSHREEGQG GGACGGYCSV L

RAB18 belongs to a family of Ras-related small GTPase which is lipid-anchored to the cytoplasmic side of the cell membrane. RAB18 takes part in apical recycling, endocytosis and protein transport between early endosomes and the plasma membrane.

RAB18 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-206) and having a molecular mass of 24.5 kDa.RAB18 is fused to a 15 amino acid T7-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RAB18: a small G protein that plays a role in apical endocytosis/recycling. May be involved in transport between the plasma membrane and early endosomes.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: Golgi apparatus; plasma membrane; intracellular

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: intracellular protein transport; eye development; metabolic process; small GTPase mediated signal transduction; brain development; Rab protein signal transduction

Disease: Warburg Micro Syndrome 3

NCBI Summary:The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q9NP72
NCBI GenInfo Identifier:12230528
NCBI Gene ID:22931
NCBI Accession:Q9NP72.1
UniProt Secondary Accession:Q9NP72,Q53FX8, Q56UN9, Q6FIH1, B3KMC7, B7Z333, D3DRW1
UniProt Related Accession:Q9NP72
Molecular Weight:206
NCBI Full Name:Ras-related protein Rab-18
NCBI Synonym Full Names:RAB18, member RAS oncogene family
NCBI Official Symbol:RAB18��
NCBI Official Synonym Symbols:WARBM3; RAB18LI1��
NCBI Protein Information:ras-related protein Rab-18; RAB18 small GTPase
UniProt Protein Name:Ras-related protein Rab-18
Protein Family:Ras-related protein
UniProt Gene Name:RAB18��
UniProt Entry Name:RAB18_HUMAN
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