Human RAB14 Recombinant Protein (RPPB4346)
- SKU:
- RPPB4346
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61106
Description
| Product Name: | Human RAB14 Recombinant Protein |
| Product Code: | RPPB4346 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAB14 |
| Synonyms: | RAB14 member RAS oncogene family, FBP, bA165P4.3 (member RAS oncogene family), F protein-binding protein 1, ras-related protein Rab-14, small GTP binding protein RAB14. |
| Source: | Escherichia Coli |
| Physical Appearance: | RAB14 is supplied as a sterile filtered clear solution. |
| Formulation: | RAB14 protein 0.5mg/ml is supplied in 20mM Tris-HCL, pH-8, 0.1M NaCl, 1mM DTT and 20% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMATAPYN YSYIFKYIII GDMGVGKSCL LHQFTEKKFM ADCPHTIGVE FGTRIIEVSG QKIKLQIWDT AGQERFRAVT RSYYRGAAGA LMVYDITRRS TYNHLSSWLT DARNLTNPNT VIILIGNKAD LEAQRDVTYE EAKQFAEENG LLFLEASAKT GENVEDAFLE AAKKIYQNIQ DGSLDLNAAE SGVQHKPSAP QGGRLTSEPQ PQREGCGC |
RAB14 belongs to the RAB protein family, low molecular mass monomeric GTPases which is found on the cytoplasmic surfaces of distinct membrane bound organelles. RAB14 has a role in vesicular trafficking and neurotransmitter release throughout the body and is expressed at high levels in brain, lung, kidney, spleen and thymus. In addition, RAB14 takes part in the biosynthetic/recycling pathway between the Golgi and endosomal compartments.
RAB14 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 238 amino acids (1-215) and having a molecular mass of 26.3 kDa.The RAB14 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB14: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 9q33.2 Cellular Component: cilium; cytoplasmic vesicle membrane; cytosol; early endosome; early endosome membrane; Golgi stack; intracellular; intracellular membrane-bound organelle; late endosome; lysosomal membrane; lysosome; nuclear envelope-endoplasmic reticulum network; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; recycling endosome; recycling endosome membrane; rough endoplasmic reticulum; trans-Golgi network transport vesicle Molecular Function:GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding Biological Process: embryonic development; endocytic recycling; fibroblast growth factor receptor signaling pathway; Golgi to endosome transport; neutrophil degranulation; phosphatidylinositol biosynthetic process; regulation of endocytosis; regulation of protein localization |
| NCBI Summary: | RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009] |
| UniProt Code: | P61106 |
| NCBI GenInfo Identifier: | 85700392 |
| NCBI Gene ID: | 51552 |
| NCBI Accession: | P61106.4 |
| UniProt Secondary Accession: | P61106,P35287, Q5JVD4, Q6Q7K5, Q969L0, Q9UI11, B3KR31 |
| UniProt Related Accession: | P61106 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Ras-related protein Rab-14 |
| NCBI Synonym Full Names: | RAB14, member RAS oncogene family |
| NCBI Official Symbol: | RAB14�� |
| NCBI Official Synonym Symbols: | FBP; RAB-14�� |
| NCBI Protein Information: | ras-related protein Rab-14 |
| UniProt Protein Name: | Ras-related protein Rab-14 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB14�� |
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