Human RAB10 Recombinant Protein (RPPB4343)
- SKU:
- RPPB4343
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61026
Description
| Product Name: | Human RAB10 Recombinant Protein |
| Product Code: | RPPB4343 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAB10 |
| Synonyms: | Ras-related GTP-binding protein RAB10, Ras-related protein Rab-10, RAB10, Rab10, member RAS oncogene family. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAB10 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAKKTYDLLF KLLLIGDSGV GKTCVLFRFS DDAFNTTFIS TIGIDFKIKT VELQGKKIKL QIWDTAGQER FHTITTSYYR GAMGIMLVYD ITNGKSFENI SKWLRNIDEH ANEDVERMLL GNKCDMDDKR VVPKGKGEQI AREHGIRFFE TSAKANINIE KAFLTLAEDI LRKTPVKEPN SENVDISSGG GVTGWKSKCC |
RAB10, Member RAS Oncogene Family (RAB10) belongs to the Ras superfamily of small GTP-binding proteins. RAB10 is a key regulator of endocytic recycling, particularly in the basolateral recycling pathways of polarized epithelial cells. It is required for the recruitment of CNT-1 to endosomal membranes in the intestinal epithelium.
RAB10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa. RAB10 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB10: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: Golgi apparatus; phagocytic vesicle membrane; endoplasmic reticulum membrane; recycling endosome; cytoplasmic vesicle membrane; focal adhesion; recycling endosome membrane; exocyst; plasma membrane; endosome membrane; trans-Golgi network; endosome Molecular Function:GTPase activity; GDP binding; GTP binding; myosin V binding Biological Process: metabolic process; establishment of neuroblast polarity; protein secretion; endosome transport; regulation of exocytosis; vesicle-mediated transport; polarized epithelial cell differentiation; intracellular protein transport; Golgi to plasma membrane transport; antigen processing and presentation; cellular response to insulin stimulus; axonogenesis; Golgi to plasma membrane protein transport; Rab protein signal transduction; vesicle docking during exocytosis |
| NCBI Summary: | RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009] |
| UniProt Code: | P61026 |
| NCBI GenInfo Identifier: | 46577638 |
| NCBI Gene ID: | 10890 |
| NCBI Accession: | P61026.1 |
| UniProt Related Accession: | P61026 |
| Molecular Weight: | 22.5kDa |
| NCBI Full Name: | Ras-related protein Rab-10 |
| NCBI Synonym Full Names: | RAB10, member RAS oncogene family |
| NCBI Official Symbol: | RAB10�� |
| NCBI Protein Information: | ras-related protein Rab-10 |
| UniProt Protein Name: | Ras-related protein Rab-10 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB10�� |
| UniProt Entry Name: | RAB10_HUMAN |
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