Human R-Spondin 1/RSPO1 Recombinant Protein (RPES1997)
- SKU:
- RPES1997
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human R-Spondin 1/RSPO1 Recombinant Protein
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
| Product Name: | Human R-Spondin 1/RSPO1 Recombinant Protein (RPES1997) |
| Product Code: | RPES1997 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | RSPO1, R-spondin1, RP11-566C13.1, CRISTIN3, FLJ40906, RSPO Rspo1, R-spondin, Rspondin, RP23-325M14.2, Roof plate-specific spondin-1 |
| Accession: | NP_001033722.1 |
| Sequence: | Met 1-Ala 146 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to bind recombinant mouse CD36 in a functional ELISA. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the amino acids (Met 1-Ala 146) of human RSPO1 (NP_001033722.1) was expressed, fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14 kDa |
| AP Mol Mass: | 23 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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