Enzymes Recombinant Proteins

Human QTRT1 Recombinant Protein (RPPB2239)

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SKU:
RPPB2239
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BXR0
Research Area:
Enzymes

Description

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Product Name:Human QTRT1 Recombinant Protein
Product Code:RPPB2239
Size:5µg
Species:Human
Target:QTRT1
Synonyms:Queuine TRNA-Ribosyltransferase 1, TRNA-GuanineTransglycosylase, TGT, Guanine Insertion Enzyme, EC 2.4.2.29, TGUT, QueuineTRNA-Ribosyltransferase, TGT, Catalytic Subunit, TGT, 43-KD Subunit, FP3235, QueuinetRNA-ribosyltransferase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:QTRT1 protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEFMAGAA TQASLESAPR IMRLVAECSR SRARAGELWL PHGTVATPVFMPVGTQATMK GITTEQLDAL GCRICLGNTY HLGLRPGPEL IQKANGLHGF MNWPHNLLTD SGGFQMVSLVSLSEVTEEGV RFRSPYDGNE TLLSPEKSVQ IQNALGSDII MQLDDVVSST VTGPRVEEAM YRSIRWLDRCIAAHQRPDKQ NLFAIIQGGL DADLRATCLE EMTKRDVPGF AIGGLSGGES KSQFWRMVAL STSRLPKDKP RYLMGVGYATDLVVCVALGC DMFDCVFPTR TARFGSALVP TGNLQLRKKV FEKDFGPIDP ECTCPTCQKH SRAFLHALLHSDNTAALHHL TVHNIAYQLQ LMSAVRTSIV EKRFPDFVRD FMGAMYGDPT LCPTWATDAL ASVGITLG

Queuine TRNA-Ribosyltransferase 1 also known as QTRT1 is a member of thequeuine tRNA-ribosyltransferase family. QTRT1 interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. Furthermore, QTRT1 exchangesqueuine for the guanine at the wobble position of tRNAs with GUN� anticodons (tRNA-Asp, -Asn, -His and� -Tyr), in this manner forming thehypermodified nucleoside queuosine (Q)(7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

QTRT1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 428 amino acids (1-403 a.a) andhaving a molecular mass of 46.7kDa.QTRT1 is fused to a 25 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:QTRT1: Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). Belongs to the queuine tRNA-ribosyltransferase family.Protein type: Mitochondrial; RNA processing; EC 2.4.2.29; TransferaseChromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; mitochondrial outer membraneMolecular Function: queuine tRNA-ribosyltransferase activityBiological Process: queuosine biosynthetic process; tRNA modification
UniProt Protein Details:
NCBI Summary:This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
UniProt Code:Q9BXR0
NCBI GenInfo Identifier:239938842
NCBI Gene ID:81890
NCBI Accession:Q9BXR0.3
UniProt Secondary Accession:Q9BXR0,Q96BQ4, Q9BXQ9, B4DFM7
UniProt Related Accession:Q9BXR0
Molecular Weight:24,015 Da
NCBI Full Name:Queuine tRNA-ribosyltransferase
NCBI Synonym Full Names:queuine tRNA-ribosyltransferase catalytic subunit 1
NCBI Official Symbol:QTRT1��
NCBI Official Synonym Symbols:TGT; TGUT; FP3235��
NCBI Protein Information:queuine tRNA-ribosyltransferase
UniProt Protein Name:Queuine tRNA-ribosyltransferase
UniProt Synonym Protein Names:Guanine insertion enzyme; tRNA-guanine transglycosylase
Protein Family:Queuine tRNA-ribosyltransferase
UniProt Gene Name:QTRT1��
UniProt Entry Name:TGT_HUMAN
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