Enzymes Recombinant Proteins

Human PTPN4 Recombinant Protein (RPPB2641)

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SKU:
RPPB2641
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P29074
Research Area:
Enzymes

Description

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Product Name:Human PTPN4 Recombinant Protein
Product Code:RPPB2641
Size:20µg
Species:Human
Target:PTPN4
Synonyms:Protein Tyrosine Phosphatase, Non-Receptor Type 4(Megakaryocyte), Protein-Tyrosine Phosphatase MEG1, PTPase-MEG1, EC 3.1.3.48,MEG, Tyrosine-Protein Phosphatase Non-Receptor Type 4, MegakaryocyteProtein-Tyrosine Phosphatase, Protein Tyrosine Phosphatase MEG1, MegakaryocytePhosphatase, PTPMEG1, PTPMEG, Tyrosine-protein phosphatase non-receptor type 4,Protein-tyrosine phosphatase MEG1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PTPN4 protein solution (1mg/ml) containing 20mM Trisbuffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MVLTQFDQLY RKKPGMTMSC AKLPQNISKN RYRDISPYDA TRVILKGNED YINANYINMEIPSSSIINQY IACQGPLPHT CTDFWQMTWE QGSSMVVMLT TQVERGRVKC HQYWPEPTGS SSYGCYQVTCHSEEGNTAYI FRKMTLFNQE KNESRPLTQI QYIAWPDHGV PDDSSDFLDF VCHVRNKRAG KEEPVVVHCSAGIGRTGVLI TMETAMCLIE CNQPVYPLDI VRTMRDQRAM MIQTPSQYRF VCEAILKVYE

Protein Tyrosine Phosphatase Non Receptor Type-4, also known as PTPN4belongs to the protein tyrosine phosphatase, PTP family. PTPs are identified assignaling molecules which regulate a variety of cellular processes as well ascell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN4is broadly expressed non-receptor protein tyrosine phosphatase. In addition, PTPN4interacts with glutamate receptor delta 2 & epsilon, and affects glutamatereceptors signaling and/or in regulation of their activities through tyrosine dephosphorylation.

PTPN4 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 280 amino acids (655-913 a.a) and having amolecular mass of 32kDa.PTPN4 is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
UniProt Protein Details:

Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm

Molecular Function:protein binding; cytoskeletal protein binding; non-membrane spanning protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
UniProt Code:P29074
NCBI GenInfo Identifier:131531
NCBI Gene ID:5775
NCBI Accession:P29074.1
UniProt Secondary Accession:P29074,Q9UDA7, B2RBV8,
UniProt Related Accession:P29074
Molecular Weight:926
NCBI Full Name:Tyrosine-protein phosphatase non-receptor type 4
NCBI Synonym Full Names:protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
NCBI Official Symbol:PTPN4��
NCBI Official Synonym Symbols:MEG; PTPMEG; PTPMEG1��
NCBI Protein Information:tyrosine-protein phosphatase non-receptor type 4; PTPase-MEG1; megakaryocyte phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase
UniProt Protein Name:Tyrosine-protein phosphatase non-receptor type 4
UniProt Synonym Protein Names:Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1
Protein Family:Tyrosine-protein phosphatase non-receptor
UniProt Gene Name:PTPN4��
UniProt Entry Name:PTN4_HUMAN
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