Enzymes Recombinant Proteins

Human PSMA8 Recombinant Protein (RPPB2203)

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SKU:
RPPB2203
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8TAA3
Research Area:
Enzymes

Description

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Product Name:Human PSMA8 Recombinant Protein
Product Code:RPPB2203
Size:10µg
Species:Human
Target:PSMA8
Synonyms:Proteasome subunit alpha type-7-like, PSMA8, PSMA7L.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PSMA8 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAGLTA DARVVINRAR VECQSHKLTV EDPVTVEYIT RFIATLKQKY TQSNGRRPFG ISALIVGFDD DGISRLYQTD PSGTYHAWKA NAIGRSAKTV REFLEKNYTE DAIASDSEAI KLAIKALLEV VQSGGKNIEL AIIRRNQPLK MFSAKEVELY VTEIEKEKEE AEKKKSKKSV

Proteasome subunit alpha type-8 (PSMA8) is a member of the peptidase T1A family. PSMA8 is a multicatalytic proteinase complex which is distinguished by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The PSMA8 subunit may be testis-specific.

PSMA8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 270 amino acids (1-250) and having a molecular mass of 30kDa.PSMA8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH
UniProt Protein Details:

By similarity.

Catalytic activity: Cleavage of peptide bonds with very broad specificity.

Subunit structure: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel

By similarity. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity.

Sequence similarities: Belongs to the peptidase T1A family.

UniProt Code:Q8TAA3
NCBI GenInfo Identifier:68303565
NCBI Gene ID:143471
NCBI Accession:NP_001020268.1
UniProt Secondary Accession:Q8TAA3,Q8IVP4, Q8TA98, Q8TAA2, B0YJ75,
UniProt Related Accession:Q8TAA3
Molecular Weight:28,530 Da
NCBI Full Name:proteasome subunit alpha type-7-like isoform 3
NCBI Synonym Full Names:proteasome (prosome, macropain) subunit, alpha type, 8
NCBI Official Symbol:PSMA8��
NCBI Official Synonym Symbols:PSMA7L��
NCBI Protein Information:proteasome subunit alpha type-7-like
UniProt Protein Name:Proteasome subunit alpha type-7-like
Protein Family:Proteasome
UniProt Gene Name:PSMA8��
UniProt Entry Name:PSA7L_HUMAN
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