Immune Checkpoint Recombinant Proteins

Human PSMA Recombinant Protein (hFc Tag) (HDPT0171)

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SKU:: HDPT0171
UPC:
MPN:
Product Type:: Recombinant Protein
Species:: Human
Research Area:: Immune Checkpoint

Description
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Description

Human PSMA Recombinant Protein (hFc Tag)

Description:	This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Product name:	Human PSMA Recombinant Protein (hFc Tag)
Synonyms:	FGCP, FOLH, GCP2, GCPII, mGCP, NAALAD1, NAALAdase, PSM, PSMA
Type:	protein
Size:	50 µg
Name:	PSMA
Origin:	Human
Source:	HEK293
Protein Type:	Recombinant
Application:	Contact Technical Support
Purity:	> 90%
Purification:	affinity purification
Format:	Lyophilized
Conjugate:	N-Human Fc
Storage:	Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:	Research use only
Buffer:	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:	Reconstitute with deionized water
Sequence:	hFc（Glu99-Ala330）+PSMA（Lys44-Ala750）
Gene ID:	2346
Uniprot:	Q04609
Molecular Weight:	130 kDa