Human PSEN2 / Presenilin-2 ELISA Kit

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SKU:
HUFI01173
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P49810
Sensitivity:
9.375pg/ml
Range:
15.625-1000pg/ml
ELISA Type:
Sandwich
Synonyms:
PSEN2, Presenilin-2, PS-2, STM-2, E5-1, AD3LP, AD5, AD4, PSNL2
Reactivity:
Human
Research Area:
Signal Transduction

Description

Human PSEN2 / Presenilin-2 ELISA Kit

Presenilins are involved in the processing of APP, according to their effects on beta-secretase, an enzyme that cuts APP. PSEN2/Presenilin-2 participates in Notch receptor cleavage, either directly affecting gamma-secretase activity or functions as a protease. Two alternatively spliced transcript variants of PSEN2 have been verified. Alzheimer's Disease 4 and Cardiomyopathy are two examples of PSEN2-related disorders. PSEN2/Presenilin-2 is associated with NOTCH2 activation and NOTCH1 signaling pathways.

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