Enzymes Recombinant Proteins

Human PSAT1 Recombinant Protein (RPPB2195)

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SKU:
RPPB2195
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y617
Research Area:
Enzymes

Description

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Product Name:Human PSAT1 Recombinant Protein
Product Code:RPPB2195
Size:20µg
Species:Human
Target:PSAT1
Synonyms:Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT, PSAT1, PSA, EPIP.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The PSAT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMDAPRQ VVNFGPGPAK LPHSVLLEIQ KELLDYKGVG ISVLEMSHRS SDFAKIINNT ENLVRELLAV PDNYKVIFLQ GGGCGQFSAV PLNLIGLKAG RCADYVVTGA WSAKAAEEAK KFGTINIVHP KLGSYTKIPD PSTWNLNPDA SYVYYCANET VHGVEFDFIP DVKGAVLVCD MSSNFLSKPV DVSKFGVIFA GAQKNVGSAG VTVVIVRDDL LGFALRECPS VLEYKVQAGN SSLYNTPPCF SIYVMGLVLE WIKNNGGAAA MEKLSSIKSQ TIYEIIDNSQ GFYVCPVEPQ NRSKMNIPFR IGNAKGDDAL EKRFLDKALE LNMLSLKGHR SVGGIRASLY NAVTIEDVQK LAAFMKKFLE MHQL

Phosphoserine aminotransferase (PSAT1) catalyzes the conversion of 3-phosphohydroxypyruvate into 3-phosphoserine which is dephosphorylated consequently by phosphoserine phosphatase to form L-serine. PSAT1 is probably a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. PSAT1 is expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. Defects in the PSAT1 gene are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is distinguished biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.

PSAT1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 394 amino acids (1-370) and having a molecular mass of 42.9kDa.PSAT1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
NCBI Summary:This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013]
UniProt Code:Q9Y617
NCBI GenInfo Identifier:20141815
NCBI Gene ID:29968
NCBI Accession:Q9Y617.2
UniProt Secondary Accession:Q9Y617,Q5T7G5, Q5T7G6, Q96AW2, Q9BQ12,
UniProt Related Accession:Q9Y617
Molecular Weight:41 kDa
NCBI Full Name:Phosphoserine aminotransferase
NCBI Synonym Full Names:phosphoserine aminotransferase 1
NCBI Official Symbol:PSAT1��
NCBI Official Synonym Symbols:PSA; EPIP; NLS2; PSAT; PSATD��
NCBI Protein Information:phosphoserine aminotransferase
UniProt Protein Name:Phosphoserine aminotransferase
UniProt Synonym Protein Names:Phosphohydroxythreonine aminotransferase; PSAT
Protein Family:Phosphoserine aminotransferase
UniProt Gene Name:PSAT1��
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