Enzymes Recombinant Proteins

Human PRTFDC1 Recombinant Protein (RPPB2194)

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RPPB2194

Description

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Product Name:Human PRTFDC1 Recombinant Protein
Product Code:RPPB2194
Size:20µg
Species:Human
Target:PRTFDC1
Synonyms:Phosphoribosyltransferase domain-containing protein 1, PRTFDC1, HHGP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PRTFDC1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.1M NaCl and 1mM DTT.
Stability:PRTFDC1 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAGSSEE APDYGRGVVI MDDWPGYDLN LFTYPQHYYG DLEYVLIPHG IIVDRIERLA KDIMKDIGYS DIMVLCVLKG GYKFCADLVE HLKNISRNSD RFVSMKVDFI RLKSYRNDQS MGEMQIIGGD DLSTLAGKNV LIVEDVVGTG RTMKALLSNI EKYKPNMIKV ASLLVKRTSR SDGFRPDYAG FEIPNLFVVG YALDYNEYFR DLNHICVINE HGKEKYRV

Phosphoribosyltransferase domain-containing protein 1 (PRTFDC1) is a member of the purine/pyrimidine phosphoribosyltransferase family. PRTFDC1 has a low, barely measurable phosphoribosyltransferase activity (in vitro). PRTFDC1 can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). PRTFDC1 is not expected to impact purine metabolism or GMP salvage.

PRTFDC1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 248 amino acids (1-225 a.a.) and having a molecular mass of 28.1kDa.PRTFDC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PRTFDC1: Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. Belongs to the purine/pyrimidine phosphoribosyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: cytosol

Molecular Function:hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; protein binding; protein homodimerization activity

Biological Process: adenine salvage; GMP catabolic process; GMP salvage; guanine salvage; hypoxanthine metabolic process; IMP salvage

UniProt Code:Q9NRG1
NCBI GenInfo Identifier:74752920
NCBI Gene ID:56952
NCBI Accession:Q9NRG1.1
UniProt Secondary Accession:Q9NRG1,Q53HA7, Q59EL9, Q5VV18, Q5VV20, B7Z1Z3,
UniProt Related Accession:Q9NRG1
Molecular Weight:19,983 Da
NCBI Full Name:Phosphoribosyltransferase domain-containing protein 1
NCBI Synonym Full Names:phosphoribosyl transferase domain containing 1
NCBI Official Symbol:PRTFDC1��
NCBI Official Synonym Symbols:HHGP��
NCBI Protein Information:phosphoribosyltransferase domain-containing protein 1
UniProt Protein Name:Phosphoribosyltransferase domain-containing protein 1
Protein Family:Phosphoribosyltransferase domain-containing protein
UniProt Gene Name:PRTFDC1��
UniProt Entry Name:PRDC1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NRG1
Research Area:
Enzymes
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