Enzymes Recombinant Proteins

Human PRSS7 Recombinant Protein (RPPB2191)

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SKU:
RPPB2191
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P98073
Research Area:
Enzymes

Description

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Product Name:Human PRSS7 Recombinant Protein
Product Code:RPPB2191
Size:20µg
Species:Human
Target:PRSS7
Synonyms:PRSS7,ENTK,Protease, Serine, 7 (Enterokinase), Transmembrane Protease, Serine 15, Serine Protease 7, Enteropeptidase, EC 3.4.21.9, Transmembrane Protease Serine 15,Enterokinase Catalytic Subunit, Proenterokinase, Enterokinase, EC 3.4.21.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The PRSS7 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MAIVGGSNAK EGAWPWVVGL YYGGRLLCGA SLVSSDWLVS AAHCVYGRNL EPSKWTAILG LHMKSNLTSP QTVPRLIDEI VINPHYNRRR KDNDIAMMHL EFKVNYTDYI QPICLPEENQ VFPPGRNCSI AGWGTVVYQG TTANILQEAD VPLLSNERCQ QQMPEYNITE NMICAGYEEG GIDSCQGDSG GPLMCQENNR WFLAGVTSFG YKCALPNRPG VYARVSRFTE WIQSFLH

Protease Serine 7, also known as PRSS7, is in charge of initiating theactivation of pancreatic proteolytic proenzymes such as trypsin, chymotrypsinand carboxypeptidase A. PRSS7 catalyzes the conversion of trypsinogen totrypsin which in turn activates other proenzymes including chymotrypsinogen,procarboxypeptidases, as well as proelastases.

PRSS7 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids (785-1019 a.a.) and having a molecular mass of 26.4kDa. The PRSS7 is purified by proprietary chromatographic techniques.

UniProt Protein Function:PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:EC 3.4.21.9; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: brush border

Molecular Function:protein binding

Disease: Enterokinase Deficiency

NCBI Summary:This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
UniProt Code:P98073
NCBI GenInfo Identifier:317373442
NCBI Gene ID:5651
NCBI Accession:P98073.3
UniProt Secondary Accession:P98073,Q2NKL7,
UniProt Related Accession:P98073
Molecular Weight:Calculated MW: 112kDaObserved MW: 113kDa
NCBI Full Name:Enteropeptidase
NCBI Synonym Full Names:transmembrane protease, serine 15
NCBI Official Symbol:TMPRSS15��
NCBI Official Synonym Symbols:ENTK; PRSS7��
NCBI Protein Information:enteropeptidase
UniProt Protein Name:Enteropeptidase
UniProt Synonym Protein Names:Enterokinase; Serine protease 7; Transmembrane protease serine 15
Protein Family:Enteropeptidase
UniProt Gene Name:TMPRSS15��
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