Enzymes Recombinant Proteins

Human PRSS3 Recombinant Protein (RPPB2190)

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RPPB2190

Description

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Product Name:Human PRSS3 Recombinant Protein
Product Code:RPPB2190
Size:10µg
Species:Human
Target:PRSS3
Synonyms:Protease, Serine, 3, Protease,Serine, 4 (Trypsin 4, Brain), Brain Trypsinogen, Mesotrypsinogen, Mesotrypsin,Trypsin III, EC 3.4.21.4 4, Trypsin IV, PRSS4, TRY3, TRY4 Protease, Serine, 3 (Mesotrypsin), Pancreatic Trypsinogen III, Serine Protease 3,Serine Protease 4, Trypsinogen IV, Trypsinogen 4, Trypsinogen 5, EC 3.4.21, MTG,T9.
Source:Sf9 Insect cells
Physical Appearance:Sterilefiltered colorless solution.
Formulation:PRSS3 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPIVGGYTC EENSLPYQVS LNSGSHFCGG SLISEQWVVS AAHCYKTRIQVRLGEHNIKV LEGNEQFINA AKIIRHPKYN RDTLDNDIML IKLSSPAVIN ARVSTISLPT APPAAGTECLISGWGNTLSF GADYPDELKC LDAPVLTQAE CKASYPGKIT NSMFCVGFLE GGKDSCQRDS GGPVVCNGQLQGVVSWGHGC AWKNRPGVYT KVYNYVDWIK DTIAANSHHH HHH

PRSS3 is a trypsinogen, and a member of the trypsin family of serine proteases. PRSS3 is expressed in the pancreas and brain and is unaffected by common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. PRSS3 is restricted to the locus of T cell receptor beta variable orphans on chromosome 9. 4 different isoforms encoded by 4 transcript variants were identified for this gene.

PRSS3 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 233 amino acids (81-304a.a.) and having a molecular mass of 25.3kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).PRSS3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.
UniProt Protein Details:
NCBI Summary:This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
UniProt Code:P35030
NCBI GenInfo Identifier:209572698
NCBI Gene ID:5646
NCBI Accession:P35030.2
UniProt Secondary Accession:P35030,P15951, Q15665, Q5VXV0, Q6ISJ4, Q9UQV3, A8CED1 A8CED3, A9Z1Y4, E7ES07
UniProt Related Accession:P35030
Molecular Weight:25,924 Da
NCBI Full Name:Trypsin-3
NCBI Synonym Full Names:protease, serine 3
NCBI Official Symbol:PRSS3��
NCBI Official Synonym Symbols:T9; MTG; TRY3; TRY4; PRSS4��
NCBI Protein Information:trypsin-3
UniProt Protein Name:Trypsin-3
UniProt Synonym Protein Names:Brain trypsinogen; Mesotrypsinogen; Serine protease 3; Serine protease 4; Trypsin III; Trypsin IV
Protein Family:
UniProt Gene Name:PRSS3��
UniProt Entry Name:TRY3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P35030
Research Area:
Enzymes
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