Growth Factors & Cytokines Recombinant Proteins

Human Prolactin Recombinant Protein (RPPB0869)

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SKU:
RPPB0869
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01236
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human Prolactin Recombinant Protein
Product Code:RPPB0869
Size:50µg
Species:Human
Target:Prolactin
Synonyms:Mammotropin, Luteotropic hormone, Luteotropin, PRL.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM sodium Phosphate buffer pH=8 and 50mM Nacl.
Solubility:It is recommended to reconstitute the lyophilized Prolactin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prolactin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Ile-Cys
Biological Activity:The ED50 as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065ng/ml corresponding to a Specific Activity of 15,385,000IU/mg.

Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation.

Prolactin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 23007 Dalton. The Prolactin is purified by proprietary chromatographic techniques.

UniProt Protein Function:prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Cytokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: extracellular region

Molecular Function:protein binding; prolactin receptor binding; hormone activity

Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy

NCBI Summary:This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
UniProt Code:P01236
NCBI GenInfo Identifier:130930
NCBI Gene ID:5617
NCBI Accession:P01236.1
UniProt Secondary Accession:P01236,Q15199, Q92996,
UniProt Related Accession:P01236
Molecular Weight:25,876 Da
NCBI Full Name:Prolactin
NCBI Synonym Full Names:prolactin
NCBI Official Symbol:PRL��
NCBI Protein Information:prolactin; decidual prolactin
UniProt Protein Name:Prolactin
UniProt Gene Name:PRL��
UniProt Entry Name:PRL_HUMAN
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