Human Pro-Collagen I alpha Polyclonal Antibody
- SKU:
- CAB24863
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | Human Pro-Collagen I alpha Polyclonal Antibody |
| Product Code: | CAB24863 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, IF/ICC |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-161 of human Collagen I/COL1A1 (NP_000079.2). |
| Sequence: | GQVEG QDEDI PPITC VQNGL RYHDR DVWKP EPCRI CVCDN GKVLC DDVIC DETKN CPGAE VPEGE CCPVC PDGSE SPTDQ ETTGV EGPKG DTGPR GPRGP AGPPG RDGIP GQPGL PGPPG PPGPP GPPGL GGNFA P |
| Synonyms: | COL1A1, EDSC, OI1, OI2, OI3, OI4, collagen alpha-1(I) chain |
| Calculated MW: | 138kDa |
| Observed MW: | Refer to figures |
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