Human PRND Recombinant Protein (RPPB4292)
- SKU:
- RPPB4292
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UKY0
Description
| Product Name: | Human PRND Recombinant Protein |
| Product Code: | RPPB4292 |
| Size: | 10µg |
| Species: | Human |
| Target: | PRND |
| Synonyms: | Prion protein 2, DOPPEL, DPL, PrPL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PRND protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.2M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSRGIKHRI KWNRKALPST AQITEAQVAE NRPGAFIKQG RKLDIDFGAE GNRYYEANYW QFPDGIHYNG CSEANVTKEA FVTGCINATQ AANQGEFQKP DNKLHQQVLW RLVQELCSLK HCEFWLERG |
PRND is a membrane glycosylphosphatidylinositol-anchored glycoprotein which exists mainly in testis. PRND is expressed during embryogenesis, although in the central nervous system it is expressed minimally .Mutations in PRND may cause neurological disorders. PRND located on chromosome 20, about 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally analogous.
PRND Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 149 amino acids (27-152a.a) and having a molecular mass of 58.5kDa. PRND is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PRND: This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 20p13 Cellular Component: plasma membrane Biological Process: protein homooligomerization |
| NCBI Summary: | This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKY0 |
| NCBI GenInfo Identifier: | 68067934 |
| NCBI Gene ID: | 23627 |
| NCBI Accession: | Q9UKY0.2 |
| UniProt Secondary Accession: | Q9UKY0,Q9H311, Q9H312, Q9NTM4, A7U7M5, |
| UniProt Related Accession: | Q9UKY0 |
| Molecular Weight: | 176 |
| NCBI Full Name: | Prion-like protein doppel |
| NCBI Synonym Full Names: | prion protein 2 (dublet) |
| NCBI Official Symbol: | PRND�� |
| NCBI Official Synonym Symbols: | DPL; PrPLP; DOPPEL; dJ1068H6.4�� |
| NCBI Protein Information: | prion-like protein doppel; prion gene complex, downstream |
| UniProt Protein Name: | Prion-like protein doppel |
| UniProt Synonym Protein Names: | PrPLP; Prion protein 2 |
| Protein Family: | Prion-like protein doppel |
| UniProt Gene Name: | PRND�� |
| UniProt Entry Name: | PRND_HUMAN |
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