cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm, and nociception.
Product Name:
Human PRKG1 Recombinant Protein (RPES0433)
Product Code:
RPES0433
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
cGMP-Dependent Protein Kinase 1, cGK 1, cGK1, cGMP-Dependent Protein Kinase I, cGKI, PRKG1, PRKG1B, PRKGR1A, PRKGR1B
Accession:
Q13976-2
Sequence:
Gly2-Pro686
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human cGMP-Dependent Protein Kinase 1 is produced by our Mammalian expression system and the target gene encoding Gly2-Pro686 is expressed with a 6His tag at the C-terminus.
Purity:
> 80 % as determined by reducing SDS-PAGE.
Mol Mass:
78.8 kDa
AP Mol Mass:
75 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM Tris,150mM NaCl,0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF,20% glycerol,pH8.0.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Human PRKG1 ELISAPRKG1 (Protein Kinase CGMP-Dependent 1) is present in almost all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. The...
Human CSF2 Recombinant Protein (RPES5328)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!