Human PRKD2/PKD2 Recombinant Protein (RPES2662)
- SKU:
- RPES2662
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human PRKD2/PKD2 Recombinant Protein
Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein which belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves auto-inhibition by the PH domain. PRKD2 / PKD2 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.
| Product Name: | Human PRKD2/PKD2 Recombinant Protein (RPES2662) |
| Product Code: | RPES2662 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | HSPC187,nPKC-D2,PKD2 |
| Accession: | NP_057541.2 |
| Sequence: | Met 1-Leu 878 |
| Fusion tag: | N-His & GST |
| Activity: | The specific activity was determined to be ?30 nmol/min/mg using synthetic CREBtide peptide (KRREILSRRPSYR) as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the amino acid sequence (Met 1-Leu 878) of human PRKD2 (NP_057541.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 82 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 124 kDa |
| AP Mol Mass: | 120 kDa |
| Formulation: | Supplied as sterile 50mM Tris, 500mM NaCl, 0.5mM PMSF, 10% glycerol, pH 8.0 |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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