Enzymes Recombinant Proteins

Human PPP4C Recombinant Protein (RPPB2173)

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SKU:
RPPB2173
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P60510
Research Area:
Enzymes

Description

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Product Name:Human PPP4C Recombinant Protein
Product Code:RPPB2173
Size:20µg
Species:Human
Target:PPP4C
Synonyms: Serine/threonine-protein phosphatase 4 catalytic subunit,PP4, PP4C, PPH3, PPP4, PPX, PPP4C, Protein Phosphatase 4 Catalytic subunit, Proteinphosphatase X, PP-X, Pp4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PPP4C solution (1mg/1ml) contains 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAEISDL DRQIEQLRRC ELIKESEVKA LCAKAREILV EESNVQRVDSPVTVCGDIHG QFYDLKELFR VGGDVPETNY LFMGDFVDRG FYSVETFLLL LALKVRYPDR ITLIRGNHESRQITQVYGFY DECLRKYGSV TVWRYCTEIF DYLSLSAIID GKIFCVHGGL SPSIQTLDQI RTIDRKQEVPHDGPMCDLLW SDPEDTTGWG VSPRGAGYLF GSDVVAQFNA ANDIDMICRA HQLVMEGYKW HFNETVLTVWSAPNYCYRCG NVAAILELDE HLQKDFIIFE AAPQETRGIP SKKPVADYFL

Protein Phosphatase 4 Catalytic subunit (PPP4C), is a part of the Serine/threonine-protein phosphatase catalytic subunits which tskes part in dephosphorylation and regulation of HDAC3. The protein phosphatase (PP) holoenzyme is a trimeric complex compound of a regulatory subunit, a variable subunit and a catalytic subunit. 4 major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C.

PPP4C Human Recombinant produced in E. coli is a single polypeptidechain containing 330 amino acids (1-307) and having a molecular mass of 37.5kDa. PPP4C is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:PPP4C: a Ser/Thr phosphatase. A positive regulator of HPK1 and the HPK1-JNK signaling pathway. Mediates TNF-alpha-induced degradation of IRS-4 and plays a role in NF-kappaB p65 Thr dephosphorylation. Holoenzyme consists at least of a catalytic subunit PPP4C and a regulatory subunit PPP4R1.
UniProt Protein Details:

Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; microtubule organizing center; nucleus

Molecular Function:NF-kappaB-inducing kinase activity; protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: dephosphorylation

UniProt Code:P60510
NCBI GenInfo Identifier:44888846
NCBI Gene ID:5531
NCBI Accession:P60510.1
UniProt Secondary Accession:P60510,P33172,
UniProt Related Accession:P60510
Molecular Weight:307
NCBI Full Name:Serine/threonine-protein phosphatase 4 catalytic subunit
NCBI Synonym Full Names:protein phosphatase 4, catalytic subunit
NCBI Official Symbol:PPP4C��
NCBI Official Synonym Symbols:PP4; PPX; PP-X; PP4C; PPH3; PPP4��
NCBI Protein Information:serine/threonine-protein phosphatase 4 catalytic subunit; protein phosphatase X, catalytic subunit; protein phosphatase 4 (formerly X), catalytic subunit
UniProt Protein Name:Serine/threonine-protein phosphatase 4 catalytic subunit
UniProt Synonym Protein Names:Protein phosphatase X; PP-X
UniProt Gene Name:PPP4C��
UniProt Entry Name:PP4C_HUMAN
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