Enzymes Recombinant Proteins

Human PPP1R2 Recombinant Protein (RPPB2167)

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SKU:
RPPB2167
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P41236
Research Area:
Enzymes

Description

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Product Name:Human PPP1R2 Recombinant Protein
Product Code:RPPB2167
Size:20µg
Species:Human
Target:PPP1R2
Synonyms:PPP1R2, Protein phosphatase inhibitor 2, IPP-2, IPP2, Protein phosphatase 1, regulatory (inhibitor) subunit 2, Protein Phosphatase 1, Regulatory Subunit 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PPP1R2 protein solution (0. 25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 30% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAASTAS HRPIKGILKN KTSTTSSMVA SAEQPRGNVD EELSKKSQKW DEMNILATYH PADKDYGLMK IDEPSTPYHS MMGDDEDACS DTEATEAMAP DILARKLAAA EGLEPKYRIQ EQESSGEEDS DLSPEEREKK RQFEMKRKLH YNEGLNIKLA RQLISKDLH

Protein Phosphatase 1, Regulatory Subunit 2 (PPP1R2) is an inhibitor of protein-phosphatase 1 which forms heterodimer with PP1. PPP1R2 is a part of the protein phosphatase inhibitor 2 family.

PPP1R2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (1-166 a.a) and having a molecular mass of 21kDa.PPP1R2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: protein phosphatase type 1 complex

Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity

NCBI Summary:Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
UniProt Code:P41236
NCBI GenInfo Identifier:729856
NCBI Gene ID:5504
NCBI Accession:P41236.2
UniProt Related Accession:P41236
Molecular Weight:23,015 Da
NCBI Full Name:Protein phosphatase inhibitor 2
NCBI Synonym Full Names:protein phosphatase 1 regulatory inhibitor subunit 2
NCBI Official Symbol:PPP1R2��
NCBI Official Synonym Symbols:IPP2; IPP-2��
NCBI Protein Information:protein phosphatase inhibitor 2
UniProt Protein Name:Protein phosphatase inhibitor 2
Protein Family:Protein phosphatase inhibitor
UniProt Gene Name:PPP1R2��
UniProt Entry Name:IPP2_HUMAN
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