Human PPP1R11 Recombinant Protein (RPPB4286)

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SKU:
RPPB4286
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60927

Description

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Product Name:Human PPP1R11 Recombinant Protein
Product Code:RPPB4286
Size:10µg
Species:Human
Target:PPP1R11
Synonyms:HCG-V, HCGV, IPP3, TCTE5, TCTEX5, Protein phosphatase 1 regulatory subunit 11, Hemochromatosis candidate gene V protein, PPP1R11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The PPP1R11 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAEAGAG LSETVTETTV TVTTEPENRS LTIKLRKRKP EKKVEWTSDT VDNEHMGRRS SKCCCIYEKP RAFGESSTES DEEEEEGCGH THCVRGHRKG RRRATLGPTP TTPPQPPDPS QPPPGPMQH

Protein phosphatase 1 regulatory subunit 11 (PPP1R11) is located within the major histocompatibility complex class I region on chromosome 6 and is expressed in a variety of both adult and embryonic tissues. PPP1R11 acts as an inhibitor of PP1 (protein phosphatase 1), particularly showing a sensitivity toward the metal-independent and metal-dependent forms of PP1. Deletion of a portion of the q arm of chromosome 6 is related with early onset intestinal cancer, proposing the presence of a cancer vulnerability locus.

PPP1R11 Human Recombinant produced in E. coli is a single polypeptide chain containing 149 amino acids (1-126) and having a molecular mass of 16.3 kDa. PPP1R11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PPP1R11: Inhibitor of protein phosphatase 1.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 6p22.1Cellular Component: cytoplasm; nucleus; protein phosphatase type 1 complexMolecular Function: protein binding; protein phosphatase 1 binding; type 1 serine/threonine specific protein phosphatase inhibitor activityBiological Process: negative regulation of phosphoprotein phosphatase activity
UniProt Protein Details:
NCBI Summary:This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
UniProt Code:O60927
NCBI GenInfo Identifier:11386175
NCBI Gene ID:6992
NCBI Accession:NP_068778.1
UniProt Secondary Accession:O60927
UniProt Related Accession:O60927
Molecular Weight:41.3kD
NCBI Full Name:protein phosphatase 1 regulatory subunit 11
NCBI Synonym Full Names:protein phosphatase 1 regulatory inhibitor subunit 11
NCBI Official Symbol:PPP1R11��
NCBI Official Synonym Symbols:HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255��
NCBI Protein Information:protein phosphatase 1 regulatory subunit 11
UniProt Protein Name:Protein phosphatase 1 regulatory subunit 11
UniProt Synonym Protein Names:Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase inhibitor 3
Protein Family:
UniProt Gene Name:PPP1R11��
UniProt Entry Name:
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