Enzymes Recombinant Proteins

Human PPIL4 Recombinant Protein (RPPB2156)

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SKU:
RPPB2156
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WUA2
Research Area:
Enzymes

Description

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Product Name:Human PPIL4 Recombinant Protein
Product Code:RPPB2156
Size:10µg
Species:Human
Target:PPIL4
Synonyms:Peptidyl-prolyl cis-trans isomerase-like 4, PPIase, Cyclophilin-like protein PPIL4, Rotamase PPIL4, PPIL4, HDCME13P.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PPIL solution (0.5 mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 10% glycerol, 2mM DTT and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTREQLDSGR IGADEEIDDF KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV LKDKVKPKQD TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED YMPIKNTNQD IYREMGFGHY EEEESCWEKQ KSEKRDRTQN RSRSRSRERD GHYSNSHKSK YQTDLYERER SKKRDRSRSP KKSKDKEKSK YR
Biological Activity:Specific activity is > 190 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

PPIL4 belongs to an evolutionarily conserved cyclophilin-type PPIase family of proteins. PPIL4, which is ubiquitously expressed with predominant expression in kidney localizes to the nucleus and contains one PPIase cyclophilin-type domain, a lysine-rich domain, a pair of bipartite nuclear targeting sequences and one RRM (RNA recognition motif) domain. The presence of the RRM domain along with nuclear targeting sequences implies that PPIL4 may be involved in transcriptional regulation.

PPIL4 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 512 amino acids (1-492 a.a.) and having a molecular mass of 59.4kDa. The PPIL4 is purified by proprietary chromatographic techniques.

UniProt Protein Function:PPIL4: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
UniProt Protein Details:

Protein type:Isomerase; RNA-binding; EC 5.2.1.8; Cyclophilin

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytoplasm; nucleoplasm

Molecular Function:peptidyl-prolyl cis-trans isomerase activity

NCBI Summary:This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WUA2
NCBI GenInfo Identifier:74760546
NCBI Gene ID:85313
NCBI Accession:Q8WUA2.1
UniProt Secondary Accession:Q8WUA2,Q7Z3Q5, B2RD34,
UniProt Related Accession:Q8WUA2
Molecular Weight:57,225 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase-like 4
NCBI Synonym Full Names:peptidylprolyl isomerase like 4
NCBI Official Symbol:PPIL4��
NCBI Official Synonym Symbols:HDCME13P��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase-like 4
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase-like 4
UniProt Synonym Protein Names:Cyclophilin-like protein PPIL4; Rotamase PPIL4
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:PPIL4��
UniProt Entry Name:PPIL4_HUMAN
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