Enzymes Recombinant Proteins

Human PPIL3 Recombinant Protein (RPPB1548)

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SKU:
RPPB1548
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9H2H8
Research Area:
Enzymes

Description

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Product Name:Human PPIL3 Recombinant Protein
Product Code:RPPB1548
Size:20µg
Species:Human
Target:PPIL3
Synonyms:Peptidyl-prolyl cis-trans isomerase-like 3, PPIase, Cyclophilin J, CyPJ, Cyclophilin-like protein PPIL3, Rotamase PPIL3, PPIL3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PPIL3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC IFHRNIKGFM VQTGDPTGTG RGGNSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ FFITYGKQPH LDMKYTVFGK VIDGLETLDE LEKLPVNEKT YRPLNDVHIK DITIHANPFA Q
Biological Activity:Specific activity is > 280 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Peptidyl-prolyl cis-trans isomerase-like 3 (PPIL3) belongs to the cyclophilin family which catalyzes the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. PPIL3 acts either as catalyst or as molecular chaperone in protein-folding events.

PPIL3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 181 amino acids (1-161 a.a.) and having a molecular mass of 20.3kDa.PPIL3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PPIL3: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 5.2.1.8; Spliceosome; Isomerase; CyclophilinChromosomal Location of Human Ortholog: 2q33.1Molecular Function: peptidyl-prolyl cis-trans isomerase activity; protein bindingBiological Process: nuclear mRNA splicing, via spliceosome
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
UniProt Code:Q9H2H8
NCBI GenInfo Identifier:73921766
NCBI Gene ID:53938
NCBI Accession:Q9H2H8.1
UniProt Secondary Accession:Q9H2H8,Q86WF9, Q96IA9, Q9BXZ1
UniProt Related Accession:Q9H2H8
Molecular Weight:18,627 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase-like 3
NCBI Synonym Full Names:peptidylprolyl isomerase like 3
NCBI Official Symbol:PPIL3��
NCBI Official Synonym Symbols:CYPJ��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase-like 3
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase-like 3
UniProt Synonym Protein Names:Cyclophilin J; CyPJ; Cyclophilin-like protein PPIL3; Rotamase PPIL3
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:PPIL3��
UniProt Entry Name:PPIL3_HUMAN
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