Human POP4 Recombinant Protein (RPPB4279)

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RPPB4279

Description

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Product Name:Human POP4 Recombinant Protein
Product Code:RPPB4279
Size:20µg
Species:Human
Target:POP4
Synonyms:RPP29, Ribonuclease P protein subunit p29, hPOP4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:POP4 protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M UREA �and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMKSVIYH ALSQKEANDS DVQPSGAQRA EAFVRAFLKR STPRMSPQAR EDQLQRKAVV LEYFTRHKRK EKKKKAKGLS ARQRRELRLF DIKPEQQRYS LFLPLHELWK QYIRDLCSGL KPDTQPQMIQ AKLLKADLHG AIISVTKSKC PSYVGITGIL LQETKHIFKI ITKEDRLKVI PKLNCVFTVE TDGFISYIYG SKFQLRSSER SAKKFKAKGT IDL

Processing of Precursor 4 (POP4) is a member of the eukaryotic/archaeal RNase P protein component 1 family. POP4 is one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. POP4 is confined to the nucleus and associates promptly with the RNA component of this complexes.POP4 is participating in processing of precursor RNAs.

POP4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 243 amino acids (1-220 a.a.) and having a molecular mass of 27.8kDa.POP4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:POP4: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P. Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
UniProt Protein Details:

Protein type:EC 3.1.26.5; Nucleolus; RNA processing; RNA-binding; Ribonuclease

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: nucleoplasm; ribonuclease MRP complex; ribonuclease P complex

Molecular Function:protein binding; ribonuclease MRP activity; ribonuclease P activity; ribonuclease P RNA binding; RNA binding

Biological Process: rRNA processing; tRNA 5'-leader removal; tRNA processing

NCBI Summary:This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
UniProt Code:O95707
NCBI GenInfo Identifier:20141663
NCBI Gene ID:10775
NCBI Accession:O95707.2
UniProt Secondary Accession:O95707,Q5XKL7, Q6FHW9, Q9UQQ3,
UniProt Related Accession:O95707
Molecular Weight:25kDa
NCBI Full Name:Ribonuclease P protein subunit p29
NCBI Synonym Full Names:POP4 homolog, ribonuclease P/MRP subunit
NCBI Official Symbol:POP4��
NCBI Official Synonym Symbols:RPP29��
NCBI Protein Information:ribonuclease P protein subunit p29
UniProt Protein Name:Ribonuclease P protein subunit p29
Protein Family:RNases
UniProt Gene Name:POP4��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95707
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