Cell Biology Recombinant Proteins

Human Podoplanin/PDPN Recombinant Protein (RPES2251)

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RPES2251

Description

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Human Podoplanin/PDPN Recombinant Protein

Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta; lung; skeletal muscle and brain; weakly expressed in brain; kidney and liver. In placenta; PDPN expressed on the apical plasma membrane of endothelium; in lung; expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes; induces changes in cell morphology with transfected cells showing an elongated shape; numerous membrane protrusions; and major reorganization of the actin cytoskeleton; increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless; it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Product Name:Human Podoplanin/PDPN Recombinant Protein (RPES2251)
Product Code:RPES2251
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Podoplanin, Aggrus, Glycoprotein 36, Gp36, PA2.26 Antigen, T1-Alpha, T1A, PDPN, GP36
Accession:Q86YL7
Sequence:Ala23-Leu131
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Podoplanin is produced by our Mammalian expression system and the target gene encoding Ala23-Leu131 is expressed with a Fc tag at the C-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:12.1 kDa
AP Mol Mass:60-70 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4 .
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
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