Immune Checkpoint Recombinant Proteins

Human PMEL Recombinant Protein (hFc Tag) (HDPT0139)

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SKU:
HDPT0139
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human PMEL Recombinant Protein (hFc Tag)

Description:This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Product name:Human PMEL Recombinant Protein (hFc Tag)
Synonyms:D12S53E, gp100, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV
Type:protein
Size:50 µg
Name:PMEL
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Human Fc tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:PMEL(Lys25-Ala595)+hFc(Glu99-Ala330)
Gene ID:6490
Uniprot:P40967
Molecular Weight:130-250 kDa
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