Human PMAIP1 / NOXA ELISA Kit

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SKU:
HUFI01216
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q13794
Sensitivity:
46.875pg/ml
Range:
78.125-5000pg/ml
ELISA Type:
Sandwich
Synonyms:
PMAIP1, PMA-induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, NOXA, Immediate-early-response protein APR, Protein Noxa
Reactivity:
Human
Research Area:
Cell Death

Description

Human PMAIP1 / NOXA ELISA Kit

PMAIP1/NOXA is part of the pro-apoptotic BCL-2 protein family's BCL-2 homology domain 3 (BH3) subfamily, which determines if a cell commits to apoptosis. BH3-only members inactivate the anti-apoptotic BCL-2 family members during responses to death-inducing stimuli, keeping the multi-BH domain proteins BAX and BAK in an inactive state under steady-state conditions. Adult T-Cell Leukemia and Mantle Cell Lymphoma are two examples of diseases linked to PMAIP1. It regulates transcription of cell death genes via CDK-mediated phosphorylation and removal of Cdc6 and TP53. The Assay Genie PMAIP1/NOXA ELISA is a highly sensitive assay for the quantitative measurement of PMAIP1/NOXA in serum, blood, plasma, cell culture supernatant and tissue samples.

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