Growth Factors & Cytokines Recombinant Proteins

Human PLGF Recombinant Protein (RPPB0862)

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SKU:
RPPB0862
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49763
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human PLGF Recombinant Protein
Product Code:RPPB0862
Size:10µg
Species:Human
Target:PLGF
Synonyms:PIGF, PGF, PLGF-1.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:PLGF1 filtered (0.4 �m) and lyophilized from 0.5mg/ml in PBS and 5% w/v trehalose, pH 7.4.
Solubility:It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. PLGF1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHAS LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECR

PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.

PLGF1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 19-131) containing 123 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 13.8kDa (calculated).�

UniProt Protein Function:PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation

NCBI Summary:This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
UniProt Code:P49763
NCBI GenInfo Identifier:17380553
NCBI Gene ID:5228
NCBI Accession:P49763.2
UniProt Secondary Accession:P49763,Q07101, Q9BV78, Q9Y6S8,
UniProt Related Accession:P49763
Molecular Weight:19,338 Da
NCBI Full Name:Placenta growth factor
NCBI Synonym Full Names:placental growth factor
NCBI Official Symbol:PGF��
NCBI Official Synonym Symbols:PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760��
NCBI Protein Information:placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein
UniProt Protein Name:Placenta growth factor
Protein Family:Placenta growth factor
UniProt Gene Name:PGF��
UniProt Entry Name:PLGF_HUMAN
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