Growth Factors & Cytokines Recombinant Proteins

Human PLGF 2 Recombinant Protein (RPPB0864)

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SKU:
RPPB0864
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49763
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human PLGF 2 Recombinant Protein
Product Code:RPPB0864
Size:10µg
Species:Human
Target:PLGF 2
Synonyms:PIGF, PGF, PlGF-2, PLGF-2.
Source:Insect Cells
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1mg/ml) solution containing BSA.
Solubility:It is recommended to reconstitute the lyophilized Placenta Growth Factor 2 in sterile 20mM acetic acid not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Placenta Growth Factor-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PLGF2 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 80.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Biological Activity:PlGF-2 human Recombinant can bind to immobilized rh-sFlt-1 (100ng/well) with a linear range at 0.3�10ng/ml.

PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.PLGF-2 binds neuropilin-1 and 2 in a dependent manner.

Placenta Growth Factor-2 Human Recombinant produced in insect cells is a homodimer, glycosylated polypeptide chain containing 2 x 152 amino acids and having a total molecular mass of 44 kDa. The PLGF-2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation

NCBI Summary:This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
UniProt Code:P49763
NCBI GenInfo Identifier:17380553
NCBI Gene ID:5228
NCBI Accession:P49763.2
UniProt Secondary Accession:P49763,Q07101, Q9BV78, Q9Y6S8,
UniProt Related Accession:P49763
Molecular Weight:19,338 Da
NCBI Full Name:Placenta growth factor
NCBI Synonym Full Names:placental growth factor
NCBI Official Symbol:PGF��
NCBI Official Synonym Symbols:PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760��
NCBI Protein Information:placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein
UniProt Protein Name:Placenta growth factor
Protein Family:Placenta growth factor
UniProt Gene Name:PGF��
UniProt Entry Name:PLGF_HUMAN
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