Growth Factors & Cytokines Recombinant Proteins

Human Placental Lactogen Recombinant Protein (RPPB0855)

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SKU:
RPPB0855
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01243
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human Placental Lactogen Recombinant Protein
Product Code:RPPB0855
Size:50µg
Species:Human
Target:Placental Lactogen
Synonyms:Chorionic Somatomammotropin Hormone 1, CSH1, Choriomammotropin, Lactogen, CSH2, PL, CSA, CSMT, FLJ75407.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1mg/ml) solution with 0.02-0.03% NaHCO3.
Solubility:It is recommended to reconstitute the lyophilized Placental Lactogen in sterile water or 0.4% NaHCO3 adjusted to pH 8-9, not less than 100�g/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein.
Stability:Lyophilized Placental Lactogen Human Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Placental Lactogen should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 99.0% as determined by:(a) Analysis by Gel Filtration.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Val-Gln-Thr-Val-Pro
Biological Activity:Placental Lactogen Human is biologically active as evidenced by inducing proliferation of Nb2 cells.

Placental Lactogen is a polypeptide hormone that is produced by the Syncytiotrophoblasts of the Placenta, also known as chorionic somatomammotropin. It has both GH and Prolactin activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an ins. antagonist.Placental Lactogen Bovine is also capable of activating human and other heterologous GH receptors but not ruminat GH receptors.

Placental Lactogen Human Recombinant, is a single polypeptide chain containing 199 amino acids and an additional Ala at the N-terminus having a molecular mass of approximately 22.4 kDa. Placental Lactogen Recombinant is purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:P01243
NCBI GenInfo Identifier:130299
NCBI Gene ID:1442
NCBI Accession:P01243.2
UniProt Secondary Accession:P01243,P0DML2, P0DML3
UniProt Related Accession:P01243,P0DML2
Molecular Weight:25kDa
NCBI Full Name:
NCBI Synonym Full Names:chorionic somatomammotropin hormone 1
NCBI Official Symbol:CSH1��
NCBI Official Synonym Symbols:PL; CSA; CS-1; CSMT; GHB3; hCS-1; hCS-A��
NCBI Protein Information:chorionic somatomammotropin hormone 1
UniProt Protein Name:
UniProt Synonym Protein Names:
Protein Family:
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