Description
| Product Name: | Human PKNOX1 Recombinant Protein |
| Product Code: | RPPB4255 |
| Size: | 5µg |
| Species: | Human |
| Target: | PKNOX1 |
| Synonyms: | pkonx1c, PREP1, Homeobox protein PKNOX1, Homeobox protein PREP-1, PBX/knotted homeobox 1, PKNOX1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PKNOX1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ |
PBX/Knotted 1 Homeobox 1 (PKNOX1) is a DNA-binding factor which takes part in the�regulation of the transcriptional activity of AP-1 containing promoters. PKNOX1, which is also known as UEF3, PRP-1 and p64, is a Hmeobox protein. PKNOX1 forms stable complexes containing PBX proteins which synergize with AP-1 binding factors.
PKNOX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-436 a.a) and having a molecular mass of 49.7kDa. PKNOX1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PKNOX1: Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 21q22.3 Molecular Function:transcription factor activity |
| UniProt Code: | P55347 |
| NCBI GenInfo Identifier: | 115311619 |
| NCBI Gene ID: | 5316 |
| NCBI Accession: | P55347.3 |
| UniProt Secondary Accession: | P55347,O00528, Q8IWT7, |
| UniProt Related Accession: | P55347 |
| Molecular Weight: | 44,629 Da |
| NCBI Full Name: | Homeobox protein PKNOX1 |
| NCBI Synonym Full Names: | PBX/knotted 1 homeobox 1 |
| NCBI Official Symbol: | PKNOX1�� |
| NCBI Official Synonym Symbols: | PREP1; pkonx1c�� |
| NCBI Protein Information: | homeobox protein PKNOX1 |
| UniProt Protein Name: | Homeobox protein PKNOX1 |
| UniProt Synonym Protein Names: | Homeobox protein PREP-1; PBX/knotted homeobox 1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | PKNOX1�� |
| UniProt Entry Name: | PKNX1_HUMAN |
