Human PHF11 Recombinant Protein (RPPB4242)

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RPPB4242

Description

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Product Name:Human PHF11 Recombinant Protein
Product Code:RPPB4242
Size:20µg
Species:Human
Target:PHF11
Synonyms:PHD finger protein 11, BRCA1 C-terminus-associated protein, Renal carcinoma antigen NY-REN-34, PHF11, BCAP, APY, IGEL, IGER, IGHER, NYREN34, NY-REN-34, RP11-185C18.3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PHF11 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR KKPLSGNHVQ PPETMKCNTF IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK VHSIPEKLMD ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y

PHD finger protein 11 (PHF11) is a regulator of TH1-type cytokine gene expression. The decline in PHF11 expression observed with an AD-associated genotype may promote the intense TH2 reactions which characterize numerous allergic individuals. PHF11 is linked with raised total serum IgE levels, asthma and acute atopic dermatitis (AD) in children. Even though PHF11 includes a plant homeodomain, a motif frequently found in transcriptional regulators, PHF11 function of has yet been examined.

PHF11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 351 amino acids (1-331 a.a.) and having a molecular mass of 39.7kDa.PHF11 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PHF11: Positive regulator of Th1-type cytokine gene expression. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: nucleus

Molecular Function:zinc ion binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent

Disease: Asthma, Susceptibility To; Ige Responsiveness, Atopic

NCBI Summary:This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:Q9UIL8
NCBI GenInfo Identifier:259016330
NCBI Gene ID:51131
NCBI Accession:Q9UIL8.3
UniProt Related Accession:Q9UIL8
Molecular Weight:36kDa
NCBI Full Name:PHD finger protein 11
NCBI Synonym Full Names:PHD finger protein 11
NCBI Official Symbol:PHF11��
NCBI Official Synonym Symbols:APY; BCAP; IGEL; IGER; IGHER; NYREN34; NY-REN-34��
NCBI Protein Information:PHD finger protein 11
UniProt Protein Name:PHD finger protein 11
UniProt Synonym Protein Names:BRCA1 C-terminus-associated protein; Renal carcinoma antigen NY-REN-34
Protein Family:PHD finger protein
UniProt Gene Name:PHF11��
UniProt Entry Name:PHF11_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UIL8
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