Enzymes Recombinant Proteins

Human PGPEP1 Recombinant Protein (RPPB2106)

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SKU:
RPPB2106
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NXJ5
Research Area:
Enzymes

Description

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Product Name:Human PGPEP1 Recombinant Protein
Product Code:RPPB2106
Size:20µg
Species:Human
Target:PGPEP1
Synonyms:Pyroglutamyl-peptidase 1, EC 3.4.19.3, 5-oxoprolyl-peptidase, Pyroglutamyl aminopeptidase I, PAP-I, Pyroglutamyl-peptidase I, PGP-I, Pyrrolidone-carboxylate peptidase, PGPEP1, PGPI, PGP, Pcp.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The PGPEP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEQPRKA VVVTGFGPFG EHTVNASWIA VQELEKLGLG DSVDLHVYEI PVEYQTVQRL IPALWEKHSP QLVVHVGVSG MATTVTLEKC GHNKGYKGLD NCRFCPGSQC CVEDGPESID SIIDMDAVCK RVTTLGLDVS VTISQDAGRY LCDFTYYTSL YQSHGRSAFV HVPPLGKPYN ADQLGRALRA IIEEMLDLLE QSEGKINYCH KH

Pyroglutamyl-Peptidase I (PGPEP1) is an omega peptidase which detaches pyroglutamyl residues from the amino termini of peptides and proteins. PGPEP1 is a cytosolic cysteine peptidase which is expressed in most cell types. PGPEP1 enzyme has need of s a thiol-reducing agent for activity. PGPEP1 is possibly involved in the inactivation of biologically active peptides which have an amino terminal pyroglutamyl group, for instance peptides as neurotensin, luteinizing hormone releasing hormone, and thyrotropinreleasing hormone.

PGPEP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-209) and having a molecular mass of 25.5kDa.PGPEP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PGPEP1: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Belongs to the peptidase C15 family.Protein type: Protease; EC 3.4.19.3Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: cytosolBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
UniProt Code:Q9NXJ5
NCBI GenInfo Identifier:14548183
NCBI Gene ID:54858
NCBI Accession:Q9NXJ5.1
UniProt Secondary Accession:Q9NXJ5,Q8IVT1, A8K1Q3
UniProt Related Accession:Q9NXJ5
Molecular Weight:14,639 Da
NCBI Full Name:Pyroglutamyl-peptidase 1
NCBI Synonym Full Names:pyroglutamyl-peptidase I
NCBI Official Symbol:PGPEP1��
NCBI Official Synonym Symbols:PGI; PGP; Pcp; PGPI; PAP-I; PGP-I��
NCBI Protein Information:pyroglutamyl-peptidase 1
UniProt Protein Name:Pyroglutamyl-peptidase 1
UniProt Synonym Protein Names:5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase
Protein Family:Pyroglutamyl-peptidase
UniProt Gene Name:PGPEP1��
UniProt Entry Name:PGPI_HUMAN
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