Enzymes Recombinant Proteins

Human PGLS Recombinant Protein (RPPB2101)

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SKU:
RPPB2101
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95336
Research Area:
Enzymes

Description

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Product Name:Human PGLS Recombinant Protein
Product Code:RPPB2101
Size:10µg
Species:Human
Target:PGLS
Synonyms:6PGL, 6-Phosphogluconolactonase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The PGLS protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 100mM NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV PFEKHSTL

PGLS is an enzyme in the second step pentose phosphate pathway. 6-Phosphogluconolactonase is crucial for the synthesis of nucleotide sugars and NADPH, the key cause for decreasing power. PGLS transforms 6-phosphogluconolactone to 6-phosphogluconate.

PGLS produced in E.Coli is a single, non-glycosylated polypeptide chain containing 278 amino acids (1-258a.a.) and having a molecular mass of 29.7kDa.PGLS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PGLS: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
UniProt Protein Details:

Protein type:EC 3.1.1.31; Hydrolase; Carbohydrate Metabolism - pentose phosphate pathway

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol

Molecular Function:6-phosphogluconolactonase activity; protein binding

Biological Process: pentose-phosphate shunt

UniProt Code:O95336
NCBI GenInfo Identifier:7387511
NCBI Gene ID:25796
NCBI Accession:O95336.2
UniProt Related Accession:O95336
Molecular Weight:27,547 Da
NCBI Full Name:6-phosphogluconolactonase
NCBI Synonym Full Names:6-phosphogluconolactonase
NCBI Official Symbol:PGLS��
NCBI Official Synonym Symbols:6PGL; HEL-S-304��
NCBI Protein Information:6-phosphogluconolactonase
UniProt Protein Name:6-phosphogluconolactonase
UniProt Gene Name:PGLS��
UniProt Entry Name:6PGL_HUMAN
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