Human PFDN5 Recombinant Protein (RPPB4231)

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RPPB4231

Description

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Product Name:Human PFDN5 Recombinant Protein
Product Code:RPPB4231
Size:20µg
Species:Human
Target:PFDN5
Synonyms:Prefoldin subunit 5, C-Myc-binding protein Mm-1, Myc modulator 1, PFDN5, MM1, PFD5, MM-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PFDN5 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TAKA

PFDN5 is a member of the prefoldin alpha subunit family. Prefoldin (PFDN) being a ubiquitously expressed heterohexameric co-chaperone, is required for proper folding of nascent proteins, in particular, tubulin and actin. PFDN5 is one of 6 subunits of prefoldin, which is a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thus allowing them to fold properly. The PFDN5 protein may also limit the transcriptional activity of the proto-oncogene c-Myc.

PFDN5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 174 amino acids (1-154 a.a.) and having a molecular mass of 19.5kDa.PFDN5 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PFDN5: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. Belongs to the prefoldin subunit alpha family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytoplasm; nucleus; prefoldin complex

Molecular Function:protein binding; unfolded protein binding; transcription corepressor activity

Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; regulation of transcription, DNA-dependent; protein folding; retina development in camera-type eye; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q99471
NCBI GenInfo Identifier:12231038
NCBI Gene ID:5204
NCBI Accession:Q99471.2
UniProt Related Accession:Q99471
Molecular Weight:17kDa
NCBI Full Name:Prefoldin subunit 5
NCBI Synonym Full Names:prefoldin subunit 5
NCBI Official Symbol:PFDN5��
NCBI Official Synonym Symbols:MM1; MM-1; PFD5��
NCBI Protein Information:prefoldin subunit 5
UniProt Protein Name:Prefoldin subunit 5
UniProt Synonym Protein Names:C-Myc-binding protein Mm-1; Myc modulator 1
Protein Family:Prefoldin
UniProt Gene Name:PFDN5��
UniProt Entry Name:PFD5_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q99471
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