Human PFDN1 Recombinant Protein (RPPB4228)
- SKU:
- RPPB4228
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60925
Description
| Product Name: | Human PFDN1 Recombinant Protein |
| Product Code: | RPPB4228 |
| Size: | 5µg |
| Species: | Human |
| Target: | PFDN1 |
| Synonyms: | Prefoldin subunit 1, PFDN1, PFD1, PDF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PFDN1 solution (0.5 mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0) and 20% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MTELQAKVID TQQKVKLADI QIEQLNRTKK HAHLTDTEIM TLVDETNMYE GVGRMFILQS KEAIHSQLLE KQKIAEEKIK ELEQKKSYLE RSVKEAEDNI REMLMARRAQ |
PFDN1 is one of 6 subunits of prefoldin, which is a heterohexameric chaperone protein that assists in the proper folding of other proteins. The PFDN1 protein delivers nonnative target proteins, primarily actins and tubulins, to the eukaryotic cytosolic chaperonin for facilitated folding. Defects in PFDN1 presented phenotypes typical of defects in cytoskeletal function, including manifestations of ciliary dyskinesia, neuronal loss, and defects in B and T cell development and function.
PFDN1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 130 amino acids (14-122 a.a.) and having a molecular mass of 15kDa. The PFDN1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PFDN1: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Belongs to the prefoldin subunit beta family. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 5q31 Molecular Function:transcription factor activity Biological Process: cell cycle |
| NCBI Summary: | This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60925 |
| NCBI GenInfo Identifier: | 22261811 |
| NCBI Gene ID: | 5201 |
| NCBI Accession: | O60925.2 |
| UniProt Secondary Accession: | O60925,Q53F95, Q96EX6, B2RD02, |
| UniProt Related Accession: | O60925 |
| Molecular Weight: | 14,210 Da |
| NCBI Full Name: | Prefoldin subunit 1 |
| NCBI Synonym Full Names: | prefoldin subunit 1 |
| NCBI Official Symbol: | PFDN1�� |
| NCBI Official Synonym Symbols: | PDF; PFD1�� |
| NCBI Protein Information: | prefoldin subunit 1 |
| UniProt Protein Name: | Prefoldin subunit 1 |
| Protein Family: | Prefoldin |
| UniProt Gene Name: | PFDN1�� |
| UniProt Entry Name: | PFD1_HUMAN |
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