Human Periostin/OSF-2 Recombinant Protein (RPES2431)
- SKU:
- RPES2431
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human Periostin/OSF-2 Recombinant Protein
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.
| Product Name: | Human Periostin/OSF-2 Recombinant Protein (RPES2431) |
| Product Code: | RPES2431 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Osteoblast-specific factor 2,OSF-2,POSTN, Periostin,PDLPOSTN,periostin,PN |
| Accession: | NP_001129407.1 |
| Sequence: | Met 1-Gln 781 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells.When cells are added to POSTN-His coated plates (10µg/mL, 100?L/well), approximately >60% will adhere specifically after 30 minutes at 37?. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human POSTN isoform 3 (NP_001129407.1) corresponding to amino acid (Met 1-Gln 781) was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 86 kDa |
| AP Mol Mass: | 80 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Related Products
Human Periostin/OSF-2 Recombinant Protein (RPES1663)
Cell Biology Recombinant Proteins
Human Periostin Recombinant Protein (RPPB0851)
Growth Factors & Cytokines Recombinant Proteins
Human Periostin Recombinant Protein (RPPB0850)
Growth Factors & Cytokines Recombinant Proteins
Human OSF-2 / Periostin ELISA Kit
Human POSTN/OSF-2 (Periostin) ELISA Kit
QuickStep Human Periostin (OSF-2) ELISA Kit
Human POSTN/OSF-2 Recombinant Protein (His tag)
Mouse Periostin/POSTN Recombinant Protein (RPES2627)
