Human Perforin ELISA Kit

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SKU:
HUFI01208
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P14222
Sensitivity:
0.469ng/ml
Range:
0.781-50ng/ml
ELISA Type:
Sandwich
Synonyms:
PRF1, Perforin-1, Cytolysin, FLH2, Lymphocyte pore-forming protein, P1, PERF_Human, Perforin 1, PFP, Pore forming protein
Reactivity:
Human
Research Area:
Cell Biology

Description

Human Perforin ELISA Kit

Perforin is similar to complement component C9 in structure and function, which is critical for immunity. Perforin causes the creation of membrane pores that allow granzymes to be released and target cells to be destroyed via cytolysis. Whether target cell pore formation takes place in the plasma membrane or an endosomal membrane within the target cells is a point of contention. A variety of human diseases, including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and deadly autosomal recessive condition of early childhood are linked to variants.

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