Enzymes Recombinant Proteins

Human PDXK Recombinant Protein (RPPB2599)

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SKU:
RPPB2599
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00764
Research Area:
Enzymes

Description

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Product Name:Human PDXK Recombinant Protein
Product Code:RPPB2599
Size:10µg
Species:Human
Target:PDXK
Synonyms:Pyridoxal kinase, Pyridoxine kinase, PDXK, C21orf124, C21orf97, PKH, PNK, PRED79, FLJ31940, FLJ37311, MGC15873, MGC31754, MGC52346, DKFZp566A071.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PDXK solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMEEECR VLSIQSHVIR GYVGNRAATF PLQVLGFEID AVNSVQFSNH TGYAHWKGQV LNSDELQELY EGLRLNNMNK YDYVLTGYTR DKSFLAMVVD IVQELKQQNP RLVYVCDPVL GDKWDGEGSM YVPEDLLPVY KEKVVPLADI ITPNQFEAELLSGRKIHSQE EALRVMDMLH SMGPDTVVIT SSDLPSPQGS NYLIVLGSQR RRNPAGSVVM ERIRMDIRKV DAVFVGTGDL FAAMLLAWTH KHPNNLKVAC EKTVSTLHHV LQRTIQCAKA QAGEGVRPSP MQLELRMVQS KRDIEDPEIV VQATVL

PDXK converts vitamin B6 to Pyridoxal-5-phosphate (PLP), which is a vital cofactor in the intermediate metabolism of amino acids and neurotransmitters. PDXK is cytoplasmic and probably acts as a homodimer. The biological validity of the alternatively spliced transcript variants has not been determined.

PDXK Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-312 a.a.) and having a molecular mass of 37.6kDa. The PDXK is purified by proprietary chromatographic techniques.

UniProt Protein Function:PDXK: Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Belongs to the pyridoxine kinase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, other; Cofactor and Vitamin Metabolism - vitamin B6; EC 2.7.1.35

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:ATP binding; lithium ion binding; magnesium ion binding; potassium ion binding; protein homodimerization activity; pyridoxal kinase activity; pyridoxal phosphate binding; sodium ion binding; zinc ion binding

Biological Process: cell proliferation; pyridoxal 5'-phosphate salvage; pyridoxal phosphate biosynthetic process; vitamin B6 metabolic process

NCBI Summary:The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O00764
NCBI GenInfo Identifier:2811007
NCBI Gene ID:8566
NCBI Accession:O00764.1
UniProt Secondary Accession:O00764,Q7Z2Y0, Q9BS02,
UniProt Related Accession:O00764
Molecular Weight:26,827 Da
NCBI Full Name:Pyridoxal kinase
NCBI Synonym Full Names:pyridoxal (pyridoxine, vitamin B6) kinase
NCBI Official Symbol:PDXK��
NCBI Official Synonym Symbols:PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124��
NCBI Protein Information:pyridoxal kinase
UniProt Protein Name:Pyridoxal kinase
UniProt Synonym Protein Names:Pyridoxine kinase
Protein Family:Pyridoxine kinase
UniProt Gene Name:PDXK��
UniProt Entry Name:PDXK_HUMAN
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