Human PDGF-AA Recombinant Protein (RPES2146)

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SKU:
RPES2146
Product Type:
Recombinant Protein
Species:
Human

Description

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Human PDGF-AA Recombinant Protein

Platelet-derived growth factor subunit A (PDGFA); belongs to the PDGF/VEGF growth factor family. PDGFA is a secreted protein; stored in platelet alpha-granules and released by platelets upon wounding. PDGFA is potent mitogens for a variety of cell types including smooth muscle cells; connective tissue cells; bone and cartilage cells; and some blood cells. It plays an essential role in the regulation of embryonic development; cell proliferation; cell migration; survival and chemotaxis. PDGFA is required for normal lung alveolar septum formation during embryogenesis; normal development of the gastrointestinal tract; normal development of Leydig cells and spermatogenesis; normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. It plays an important role in wound healing; Signaling is modulated by the formation of heterodimers with PDGFB.

Product Name:Human PDGF-AA Recombinant Protein (RPES2146)
Product Code:RPES2146
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Platelet-derived growth factor subunit A,PDGF subunit A,PDGF-1,Platelet-derived growth factor A chain,Platelet-derived growth factor alpha polypeptide, PDGFA,PDGF1
Accession:P04085
Sequence:Ser87-Thr 211
Fusion tag:N-6His
Activity:Measured in a cell proliferation assay using BALB/C?3T3 mouse fibroblast cells.  The ED50 for this effect is 100-400 ng/ml.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Platelet-derived growth factor AA is produced by our E.coli expression system and the target gene encoding Ser87-Thr211 is expressed with a 6His tag at the N-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:15.9 kDa
AP Mol Mass:16 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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